H-ILE-ILE-GLY-LEU-MET-OH Chemical Properties

Boiling point:

866.4±65.0 °C(Predicted)

Density 

1.137±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

Soluble in DMSO

pka

3.24±0.10(Predicted)

form 

Solid

color 

White to off-white

Sequence

H-Ile-Ile-Gly-Leu-Met-OH

H-ILE-ILE-GLY-LEU-MET-OH Usage And Synthesis

Uses

β-Amyloid (31-35) is the shortest sequence of native Amyloid-β peptide that retains neurotoxic activity.

References

[1] Milton NG, et al. The amyloid-beta peptide binds to cyclin B1 and increases human cyclin-dependent kinase-1 activity. Neurosci Lett. 2002 Apr 5;322(2):131-3. DOI:10.1016/s0304-3940(02)00081-2
[2] Misiti F, et al. Fragment 31-35 of beta-amyloid peptide induces neurodegeneration in rat cerebellar granule cells via bax gene expression and caspase-3 activation. A crucial role for the redox state of methionine-35 residue. Neurochem Int. 2006 Oct;49(5):525-32. DOI:10.1016/j.neuint.2006.03.014
[3] M Jesús Pérez de Vega, et al. Synthesis and biological properties of beta-turned Abeta(31-35) constrained analogues. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2078-82. DOI:10.1016/j.bmcl.2008.01.092

H-ILE-ILE-GLY-LEU-MET-OH(149385-65-9)Related Product Information

• H-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-OH
• Glycyl-L-glutamine monohydrate
• H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH
• Amyloid β-Protein (1-42) (mouse, rat)
• Amyloid β-Peptide (1-42) (human)
• H-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-OH
• β- Amyloid (11-22)
• β-Amyloid (12-20)
• β-Amyloid (10-35), amide
• H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-OH
• AMYLOID BETA-PROTEIN (1-38)
• β- Amyloid (4-10)
• β- Amyloid (1-34)
• β-Amyloid (35-42)
• H-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH
• AMYLOID BETA-PROTEIN (1-15)
• Amyloid β-Protein (3-42)
• Amyloid beta-Protein (17-40) ammonium salt