H-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-OH Chemical Properties

Boiling point:

1805.7±65.0 °C(Predicted)

Density 

1.289±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

Soluble in DMSO

pka

3.24±0.10(Predicted)

form 

Solid

Sequence

H-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

H-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-OH Usage And Synthesis

Uses

β-Amyloid 22-35 (Amyloid β-Protein 22-35), the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution)[1].

Biological Activity

Has cytotoxic effect on cultured neurons from r at hippocampus in serum free medium. Also forms aggregates and fibrils similar to those of β-amyloid protein in senile plaque cores.

References

[1] Takadera T, et al. Toxic effect of a beta-amyloid peptide (beta 22-35) on the hippocampal neuron and its prevention. Neurosci Lett. 1993 Oct 14;161(1):41-4. DOI:10.1016/0304-3940(93)90135-8
[2] Zhou WW, et al. Decreasing oxidative stress and neuroinflammation with a multifunctional peptide rescues memory deficits in mice with Alzheimer disease. Free Radic Biol Med. 2014;74:50-63. DOI:10.1016/j.freeradbiomed.2014.06.013

H-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-OH(144189-71-9)Related Product Information

• AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE
• H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH
• Amyloid β-Protein (1-42) (mouse, rat)
• Amyloid β-Peptide (1-42) (human)
• H-ILE-ILE-GLY-LEU-MET-OH
• β-Amyloid (35-42)
• β- Amyloid (11-22)
• β-Amyloid (12-20)
• β-Amyloid (10-35), amide
• H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-OH
• AMYLOID BETA-PROTEIN (1-38)
• β- Amyloid (4-10)
• β- Amyloid (1-34)
• H-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH
• AMYLOID BETA-PROTEIN (1-15)
• Amyloid β-Protein (3-42)
• Amyloid beta-Protein (17-40) ammonium salt
• H-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-OH