Ac-DEVD-CMK
Ac-DEVD-CMK Basic information
- Product Name:
- Ac-DEVD-CMK
- Synonyms:
-
- AC-ASP-GLU-VAL-ASP-CMK
- AC-DEVD-CMK
- CASPASE-3 INHIBITOR III
- AC-ASP-GLU-VAL-ASP-CMK: AC-DEVD-CMK
- CASPASE-3 INHIBITOR III ; AC-ASP-GLU-VAL-ASP-CMK
- N-Acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-L-valinamide
- Ac-Asp-Glu-Val-Asp-chloromethylketone
- Ac-Asp-Glu-Val-Asp-chloromethylketone trifluoroacetate salt
- CAS:
- 285570-60-7
- MF:
- C21H31ClN4O11
- MW:
- 550.94
- Product Categories:
-
- Pepetides
- peptides
- peptide
- Caspase/Related Products
- Mol File:
- 285570-60-7.mol
Ac-DEVD-CMK Chemical Properties
- Boiling point:
- 1048.1±65.0 °C(Predicted)
- Density
- 1.401±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO
- pka
- 3.93±0.19(Predicted)
- form
- Powder
Ac-DEVD-CMK Usage And Synthesis
Uses
A potent, cell-permeable, and irreversible inhibitor of caspase-3; also inhibits caspases -6, -7, -8, and -10. Commonly used at concentrations up to 100 M to examine the role of caspase-3-dependent apoptosis
Uses
Ac-DEVD-CMK is a cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, -7, -8, and -10. It is commonly used at concentrations up to 100 μM to examine the role of caspase-3-dependent apoptosis in biological systems.
Biological Activity
ac-devd-cmk is a cell-permeable and irreversible caspase-3 inhibitor [1][2][3].apoptosis is a process of programmed cell death that occurs in multicellular organisms. caspase are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. caspase activation is a major event in apoptosis. caspase-3 cleaves and activates caspases 6 and 7, and is processed and activated by caspases 8, 9, and 10 [1][2][3].ac-devd-cmk (ac-asp-glu-val-asp-ch2cl) is a cell-permeable, irreversible and specific caspase-3 inhibitor. in coronary occlusion/reperfusion rat isolated hearts, ac-devd-cmk reduced infarct size (the percentage of infarction 27.8+3.3% vs control 38.5+2.6%), suggesting that caspase inhibition during early reperfusion protected myocardium against lethal reperfusion injury [1]. in bl41 cells, ac-devd-cmk partially inhibited mn2+-induced apoptosis and parp cleavage, and partially blocked b cell death by 37% even at 100 μm [2]. ac-devd-cmk significantly blocked neurotoxicity at 24 hr after 1 hr of sin-1 exposure and also protected against neurotoxicity at 24 hr after 90 min of zinc (75 μm) exposure. ac-devd-cmk completely blocked sin-1-induced activation of caspase-3 [3].
References
[1]. mocanu mm, baxter gf, yellon dm. caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury. br j pharmacol. 2000 may;130(2):197-200.
[2]. schrantz n, blanchard da, mitenne f, et al. manganese induces apoptosis of human b cells: caspase-dependent cell death blocked by bcl-2. cell death differ. 1999 may;6(5):445-53.
[3]. zhang y, wang h, li j, et al. peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation. j neurosci. 2004 nov 24;24(47):10616-27.
Ac-DEVD-CMKSupplier
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