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AC-DEVD-CHO

Basic information Safety Supplier Related

AC-DEVD-CHO Basic information

Product Name:
AC-DEVD-CHO
Synonyms:
  • Ac-DEVD-CHO,N-Acetyl-Asp-Glu-Val-Asp-al, >98%
  • AC-DEVD-CHO?, >98%
  • Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem
  • N-ACETYL-L-ALPHA-ASPARTYL-L-ALPHA-GLUTAMYL-N-(2-CARBOXY-1-FORMYLETHYL)-L VALINAMIDE
  • N-AC-ASP-GLU-VAL-ASP-CHO
  • N-ACETYL-ASP-GLU-VAL-ASP-AL
  • N-ACETYL-ASP-GLU-VAL-ASP-CHO (ALDEHYDE)
  • CPP32/APOPAIN INHIBITOR
CAS:
169332-60-9
MF:
C20H30N4O11
MW:
502.47
Product Categories:
  • peptides
  • Caspase 10
  • Caspase 3
  • Caspase 7
  • Caspase 8
  • Caspase Inhibitors
  • Caspase Inhibitors and Substrates
  • Peptides and Proteins
  • Peptides for Cell Biology
  • Protease Inhibitor Specificity Index
  • Protease Inhibitors
  • A to C
  • A-AM
  • Aldehydes
  • and Substrates
  • Apoptosis and Cell Cycle
  • Apoptosis Enzymes
  • Application Index
  • Bioactive Small Molecules
  • Biochemicals and Reagents
  • Building Blocks
  • C13-C60
  • Carbonyl Compounds
  • Caspases
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Cell Signaling Enzymes
  • Chemical Synthesis
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Enzymes
  • Inhibitors
  • Organic Building Blocks
  • Pepetides
Mol File:
169332-60-9.mol
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AC-DEVD-CHO Chemical Properties

Boiling point:
1021.1±65.0 °C(Predicted)
Density 
1.374±0.06 g/cm3(Predicted)
RTECS 
EK7643000
storage temp. 
-20°C
solubility 
H2O: 1 mg/mL
pka
4.19±0.10(Predicted)
form 
powder
color 
white
biological source
synthetic
Water Solubility 
H2O: 1mg/mL
Sensitive 
Moisture Sensitive
Sequence
N-Acetyl-Asp-Glu-Val-Asp-al
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Safety Information

WGK Germany 
3

MSDS

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AC-DEVD-CHO Usage And Synthesis

Uses

Reversible inhibitor of interleukin-1beta converting enzyme (ICE); also inhibits caspase-3 cleavage of poly(ADP-ribose) polymerase

Uses

N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples, smooth muscle cells and Jurkat T-cells.

Definition

ChEBI: A tetrapeptide consisting of two L-aspartic acid residues, an L-glutamyl residue and an L-valine residue with an acetyl group at the N-terminal and with the C-terminal carboxy group reduced to an aldehyde. It is an inhibitor of caspase-3/7.

General Description

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation.

Biochem/physiol Actions

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality.

in vivo

Compare with model group, in CI group, the concentrations of serum BUN are decreased significantly at all time points after operation and those of Cr are decreased significantly at 6 hours, then restored to those of the sham group at 12 hours and 24 hours; the concentrations of serum TNF-α, IL-6 are decreased and those of IL-10 are elevated significantly at all time points. [TNF-α (μg/L) 6 hours: 436.2±64.2 vs. 653.6±8.9, 12 hours: 233.4±85.4 vs. 579.7±137.1, 24 hours: 151.0±90.3 vs. 551.0±119.8, IL-6 (μg/L) 6 hours: 1033.2±345.8 vs. 1 595.3±159.4, 12 hours: 366.3±68.3 vs. 1 330.7±249.8, 24 hours: 241.2±208.4 vs. 815.3±572.7, IL-10 (μg/L) 6 hours: 33.6±10.4 vs. 26.6±4.5, 12 hours: 37.2±5.0 vs. 24.5±4.3, 24 hours: 38.3±5.5 vs. 18.2±1.6, all P<0.05]; the renal cell apoptosis rates are decreased significantly at all time points: apoptosis rates 6 hours: (13.9±3.2)% vs. (18.3±1.4)%, 12 hours: (10.5±3.6)% vs. (15.9±3.5)%, 24 hours: (8.4±1.8)% vs.(12.5±2.1)%[5].

IC 50

Caspase 3: 0.23 nM (Ki); Caspase-8: 0.92 nM (Ki); Caspase-7: 1.6 nM (Ki); Caspase-10: 12 nM (Ki); Caspase-1: 18 nM (Ki); Caspase-6: 31 nM (Ki); Caspase-9: 60 nM (Ki); Caspase-4: 132 nM (Ki); Caspase-5: 205 nM (Ki); Caspase-2: 1710 nM (Ki)

AC-DEVD-CHOSupplier

J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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jkinfo@jkchemical.com
Beijing Ouhe Technology Co., Ltd
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010-010-82967028 13522913783
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VDM Biochemicals
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0330-2528181
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sales@vdmbio.com
Syntechem Co.,Ltd
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Email
info@syntechem.com
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
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