AC-DEVD-PNA Chemical Properties

Boiling point:

1191.1±65.0 °C(Predicted)

Density 

1.448±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMSO (Slightly), Methanol (Slightly, Heated)

pka

2.97±0.10(Predicted)

form 

powder

color 

white

Water Solubility 

Soluble in water (partly), dimethyl sulfoxide, buffer, pH 7, and acetonitrile:methanol (1:1) (1 mg/ml).

Stability:

Hygroscopic

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

AC-DEVD-PNA Usage And Synthesis

Uses

N-Acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-(4-nitrophenyl)-L-asparagine is an para-nitro aniline chromophore cleaved by caspase.

Uses

N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide is an chromogenic substrate for Caspase 3 and CCP-32.

Uses

N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide has been used as a chromogenic substrates for determining caspase-3 and caspase-8 activities in liver tissue homogenates and caspase 3 activity in aortic vascular smooth muscle cells and neuroblastoma cell lines.

Biochem/physiol Actions

Colorimetric substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.

AC-DEVD-PNA(189950-66-1)Related Product Information

• 2-AMINO-9H-PYRIDO[2,3-B]INDOLE
• ACA
• N-acetyl aspartyl-glutaMic acid
• ALA-ALA-VAL-ALA P-NITRO-ANILIDE
• AC-ASP-PNA
• VAL-ALA P-NITROANILIDE ACETATE SALT
• H-VAL-ALA-PNA
• 4-(4-AMINOANILINO)-4-OXOBUTANOIC ACID
• AC-DEVD-PNA
• AC-DEVD-CHO
• SUC-ALA-ALA-ALA-PNA