Thalidomide-O-PEG4-azide Chemical Properties

storage temp. 

-20°C, sealed storage, away from moisture

solubility 

Soluble in Water, DMF, DCM, DMSO

form 

Oil

color 

Colorless to light yellow

Safety Information

HS Code 

2933998090

Thalidomide-O-PEG4-azide Usage And Synthesis

Description

Thalidomide-O-PEG4-Azide is a PROTAC linker that is reactive with alkyne or DBCO, BCN attached molecule via click chemistry

Uses

Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

Cereblon

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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