Thalidomide-O-PEG3-amine HCl Chemical Properties

form 

Solid

color 

White to off-white

Thalidomide-O-PEG3-amine HCl Usage And Synthesis

Uses

Thalidomide-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Biological Activity

Thalidomide 4'-ether-PEG3-amine is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus a short PEG linker ready for conjugation to a target protein ligand. This product has been recently renamed. The previous name for this product was Thalidomide - linker 11

IC 50

Cereblon

storage

Store at -20°C

References

[1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.??[Content Brief] DOI:10.1038/nature13527

Thalidomide-O-PEG3-amine HCl(2387510-82-7)Related Product Information

• Thalidomide-4-O-C8-NH2
• Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
• Thalidomide-O-PEG4-amine
• Thalidomide-O-PEG4-NHS ester
• 4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
• Acetamide, N-[2-[3-[3-(2-aminoethoxy)propoxy]propoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
• Thalidomide-O-PEG4-azide