Zelminemab
Zelminemab Basic information
- Product Name:
- Zelminemab
- Synonyms:
-
- Zelminemab
- Research Grade Zelminemab (DHE32801)
- Research Grade Zelminemab
- Zelminemab (anti-PAC1)
- CAS:
- 2225850-33-7
- MW:
- 0
- Mol File:
- Mol File
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Zelminemab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
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Zelminemab Usage And Synthesis
Uses
Zelminemab (AMG-301) is a humanized monoclonal antibody that inhibits PACAP type I (PAC1) receptor[1].
in vivo
Zelminemab (10 mg/kg; i.v.; once) reduces nociceptive neu-ronal activity in the TCC[2].
| Animal Model: | Sprague-Dawley rats, electricalstimulation was performed on the intact dura mater abovethe middle meningeal artery[2]. |
| Dosage: | 10 mg/kg |
| Administration: | i.v.; once |
| Result: | Induced an inhibition of stimulus-evoked nociceptive activity in the trigeminocervical com-plex (TCC). |
References
[1] Eloisa Rubio-Beltrán, et al. PACAP38 and PAC1 receptor blockade: a new target for headache? J Headache Pain. 2018 Aug 7;19(1):64. DOI:10.1186/s10194-018-0893-8
[2] Hoffmann J, et al. PAC-1 receptor antibody modulates nociceptive trigeminal activity in rat. Cephalalgia. 2016;36(1S):141–141.
ZelminemabSupplier
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
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Guangzhou Hongyuan Chemical Co.,Ltd
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- 15817493340
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Wuhan Chemstan Biotechnology Co., Ltd.
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- 027-65317797 15926423062
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TargetMol Chemicals Inc.
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- 4008200310
- marketing@tsbiochem.com