Ligufalimab
Ligufalimab Basic information
- Product Name:
- Ligufalimab
- Synonyms:
-
- Ligufalimab
- Research Grade Ligufalimab (DHG17606)
- Research Grade Ligufalimab
- Ligufalimab (anti-CD47)
- CAS:
- 2428381-55-7
- MW:
- 0
- Mol File:
- Mol File
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Ligufalimab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
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Ligufalimab Usage And Synthesis
Uses
Ligufalimab (AK 117) is a humanized IgG4 anti-CD47 monoclonal antibody. Ligufalimab does not induce RBC hemagglutination, and induces phagocytosis. Ligufalimab shows anti-tumor activity[1].
in vivo
Ligufalimab (0.1, 1 mg/kg for Raji xenograft, 0.2 mg/kg for MDA-MB-231 xenograft model) inhibits tumor growth in mice[1].
| Animal Model: | SCID/Beige mice (Raji xenograft model, MDA-MB-231 xenograft model)[1] |
| Dosage: | 0.1, 1 mg/kg for Raji xenograft, 0.2 mg/kg for MDA-MB-231 xenograft model |
| Administration: | I.v. |
| Result: | Inhibited tumor growth with the tumor inhibition rate of 88.56%, 63.78% at 1, 0.1 mg/kg. |
References
[1] Qu T, et al. Ligufalimab, a novel anti-CD47 antibody with no hemagglutination demonstrates both monotherapy and combo antitumor activity. J Immunother Cancer. 2022 Nov;10(11):e005517. DOI:10.1136/jitc-2022-005517
LigufalimabSupplier
Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
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ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
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Guangzhou Hongyuan Chemical Co.,Ltd
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- 15817493340
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Wuhan Chemstan Biotechnology Co., Ltd.
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- 027-65317797 15926423062
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