Keliximab
Keliximab Basic information
- Product Name:
- Keliximab
- Synonyms:
-
- Keliximab
- Idec ce91
- Immunoglobulin G 1 (human-macaca monoclonal ce91 gamma1-chain anti-human antigen cd 4), disulfide with human-macaca monoclonal ce91 lambda-chain, dimer
- Immunoglobulin G1, anti-(human cd4 (antigen)) (human-macaca monoclonal ce91 gamma1-chain), disulfide with human-macaca monoclonal ce91 lambda-chain, dimer
- Keliximab [inn]
- Research Grade Keliximab
- CAS:
- 174722-30-6
- MW:
- 0
- Mol File:
- Mol File
Keliximab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
Keliximab Usage And Synthesis
Uses
Keliximab (SB-210396) is a chimeric human/macaque IgG1 anti-CD4 monoclonal antibody with a Ki value of 1.0 nM for soluble CD4. Keliximab blocks T cell proliferation and inhibits IL-2 production. Keliximab can be used for cancer research[1][2].
in vivo
Keliximab (5-125 mg/kg; i.v., once) decreases CD4+ T cells[1].
| Animal Model: | Transgenic mice bearing human CD4 molecules on their T cells[1] |
| Dosage: | 5-125 mg/kg |
| Administration: | Intravenous injection, 5-125 mg/kg, once |
| Result: | Dose-dependently down-modulated CD4 and rapidly declined the number of circulating CD4+ T cells compared with clenoliximab. |
References
[1] Sharma A, et al. Comparative pharmacodynamics of keliximab and clenoliximab in transgenic mice bearing human CD4. J Pharmacol Exp Ther. 2000 Apr;293(1):33-41. PMID:10734150
[2] Anderson D, et al. A primatized MAb to human CD4 causes receptor modulation, without marked reduction in CD4+ T cells in chimpanzees: in vitro and in vivo characterization of a MAb (IDEC-CE9.1) to human CD4. Clin Immunol Immunopathol. 1997 Jul;84(1):73-84. DOI:10.1006/clin.1997.4363
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