Keliximab

Product Name: Keliximab
CAS No.: 174722-30-6
Chemical Name: Keliximab
Synonyms: Idec ce91;Keliximab;Keliximab [inn];Research Grade Keliximab;Immunoglobulin G 1 (human-macaca monoclonal ce91 gamma1-chain anti-human antigen cd 4), disulfide with human-macaca monoclonal ce91 lambda-chain, dimer;Immunoglobulin G1, anti-(human cd4 (antigen)) (human-macaca monoclonal ce91 gamma1-chain), disulfide with human-macaca monoclonal ce91 lambda-chain, dimer
CBNumber: CB01117516
Formula Weight: 0
MOL File: Mol file

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Keliximab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Keliximab Chemical Properties,Usage,Production

Uses

Keliximab (SB-210396) is a chimeric human/macaque IgG1 anti-CD4 monoclonal antibody with a Ki value of 1.0 nM for soluble CD4. Keliximab blocks T cell proliferation and inhibits IL-2 production. Keliximab can be used for cancer research[1][2].

in vivo

Keliximab (5-125 mg/kg; i.v., once) decreases CD4⁺ T cells^[1].

Animal Model:	Transgenic mice bearing human CD4 molecules on their T cells^[1]
Dosage:	5-125 mg/kg
Administration:	Intravenous injection, 5-125 mg/kg, once
Result:	Dose-dependently down-modulated CD4 and rapidly declined the number of circulating CD4⁺ T cells compared with clenoliximab.

References

[1] Sharma A, et al. Comparative pharmacodynamics of keliximab and clenoliximab in transgenic mice bearing human CD4. J Pharmacol Exp Ther. 2000 Apr;293(1):33-41. PMID:10734150
[2] Anderson D, et al. A primatized MAb to human CD4 causes receptor modulation, without marked reduction in CD4+ T cells in chimpanzees: in vitro and in vivo characterization of a MAb (IDEC-CE9.1) to human CD4. Clin Immunol Immunopathol. 1997 Jul;84(1):73-84. DOI:10.1006/clin.1997.4363

Keliximab Preparation Products And Raw materials

Raw materials

Preparation Products

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Keliximab Suppliers

China 10 United Kingdom 1 United States 2 Global 13

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174722-30-6, KeliximabRelated Search:

Tosylmethyl isocyanide 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE PHENYLSELENOL TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) COBALT(II) ACETYLACETONATE Benzyl isocyanide DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) TERT-BUTYL ISOCYANIDE N-BUTYLISOCYANIDE Tris(2,4-pentanedionato)chroMiuM(III) Aluminum acetylacetonate SALCOMINE METHYL ISOCYANOACETATE Ferric acetylacetonate Ethyl isocyanoacetate Cupric acetylacetonate

Keliximab

Idec ce91

Immunoglobulin G 1 (human-macaca monoclonal ce91 gamma1-chain anti-human antigen cd 4), disulfide with human-macaca monoclonal ce91 lambda-chain, dimer

Immunoglobulin G1, anti-(human cd4 (antigen)) (human-macaca monoclonal ce91 gamma1-chain), disulfide with human-macaca monoclonal ce91 lambda-chain, dimer

Keliximab [inn]

Research Grade Keliximab

174722-30-6