Nicomol Chemical Properties

Melting point:

177-180°

Boiling point:

672.42°C (rough estimate)

Density 

1.3015 (rough estimate)

refractive index 

1.6000 (estimate)

storage temp. 

2-8°C

pka

13.53±0.60(Predicted)

form 

Solid

color 

White to off-white

Safety Information

Toxicity

LD50 in mice, male and female rats (g/kg): >10, 15, <10 orally; >5, >2.5, >2.5 i.p. (Sugawara)

Nicomol Usage And Synthesis

Originator

Cholexamine,Kyorin,Japan,1971

Definition

ChEBI: Nicomol is an organic molecular entity.

Manufacturing Process

To a mixture of 60 cc of benzene, 40 cc of pyridine and 17 g of hydrochloric acid salt of nicotinic acid chloride, was added 4.5 g of 2,2,6,6- tetramethylolcyclohexanol, and the whole mixture was refuxed at 75°C to 80°C for 2.5 hours. After the mixture was cooled water was added. Precipitate formed was separated by filtration, washed thoroughly with water and dried. Recrystallization from dilute acetic acid gave 14 g of the final compound, melting point 177°C to 180°C.

Therapeutic Function

Anticholesteremic

Nicomol(27959-26-8)Related Product Information

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