ChemicalBook > Product Catalog > API > Blood System Drugs > Anticoagulant and Antiplatelet Drugs > naftazone
naftazone
naftazone Basic information
- Product Name:
- naftazone
- Synonyms:
-
- naftazone
- 2-[1-Oxonaphthalen-2(1H)-ylidene]hydrazinecarboxamide
- Karbinone
- Mediaven
- 1,2-naphthoquinone semicarbazone
- Naftazone-d6
- Hydrazinecarboxamide, 2-(1-oxo-2(1H)-naphthalenylidene)-
- naftazone USP/EP/BP
- CAS:
- 15687-37-3
- MF:
- C11H9N3O2
- MW:
- 215.21
- EINECS:
- 2397851
- Product Categories:
-
- ACTIVE PHARMACEUTICAL INGREDIENTS
- Mol File:
- 15687-37-3.mol
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naftazone Chemical Properties
- Density
- 1.40±0.1 g/cm3(Predicted)
- pka
- 12.93±0.20(Predicted)
- form
- Solid
- color
- Yellow to orange
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naftazone Usage And Synthesis
Uses
2-(1-Oxo-2(1H)-naphthalenylidene)-hydrazinecarboxamide is a novel anti-anflammatory agent as well as an anti-proliferative agent due to its 1,2-napthoquinone substructure.
Definition
ChEBI: Naftazone is a member of naphthalenes.
in vivo
Naftazone (10 and 100 mg/kg; p.o. once per day for 15 days) affects glutamate content in cerebro spinal fluid[1]. Naftazone (50 mg/kg; i.p. once per day for 5 days) affects platelet function in rats[2].
| Animal Model: | Male rats[1] |
| Dosage: | 10 and 100 mg/kg |
| Administration: | Oral gavage; 10 and 100 mg/kg once per day; for 15 days |
| Result: | Significantly reduced glutamate content in cerebro spinal fluid of rats. |
| Animal Model: | Wistar rats[2] |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injection ; 50 mg/kg once daily for 5 days |
| Result: | Reduced the height of platelet aggregation induced by ADP, significantly increased the platelet disaggregation induced by collagen and reduced fibrinogen binding to 2.5 or 5 μM ADP-stimulated platelet. |
naftazoneSupplier
LGM Pharma
- Tel
- 1-(800)-881-8210
- inquiries@lgmpharma.com
Shanghai Qiao Chemical Science Co., Ltd
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- 021-58892003
- info@qiaochem.com
Shanghai Bank Pharma Limited
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- 021-2221346380 021-54220652 17701603001
- bankpharma@163.com
Aikon International Limited
- Tel
- 025-58859352 18068836627
- dt3@aikonchem.com
TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
- marketing@targetmol.com