KIRENOL Chemical Properties

Melting point:

197.0 to 201.0 °C

Boiling point:

516.9±35.0 °C(Predicted)

Density 

1.17±0.1 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

Ethanol (Slightly), Methanol (Slightly)

form 

Solid

pka

14.06±0.20(Predicted)

color 

White to Light Yellow

CAS DataBase Reference

52659-56-0

Safety Information

Safety Statements 

24/25

RTECS 

SF7352310

HS Code 

29399990

KIRENOL Usage And Synthesis

Description

Kirenol is a diterpenoid that has been found in S. orientalis and has diverse biological activities, including anti-arthritic and anti-inflammatory properties. It inhibits Gram-positive and Gram-negative bacterial growth in disc diffusion assays with MICs ranging from 39 to 156 and 312.5 to 625 μg/ml, respectively. Kirenol also reduces K652 chronic myeloid leukemia cell viability with a 48 hour IC₅₀ value of 18.19 μg/ml and induces apoptosis. In vivo, kirenol (2 mg/kg, p.o.) reduces motor deficit, delays disease onset by approximately five days, and downregulates inflammatory CD4⁺IFN-γ⁺ Th1 cells and CD4⁺IL-17A⁺ Th17 cells in a mouse model of experimental autoimmune encephalomyelitis (EAE). Intragastric administration of kirenol (1-4 mg/kg) reduces the arthritis index, NF-kB activity, and paw swelling and increases annexin-1 expression without affecting glucocorticoid receptor α (GRα) expression in the synovium in a rat model of collagen-induced arthritis. Topical administration of kirenol (0.3-0.5% w/w) reduces edema induced by carrageenan, complete Freund''s adjuvant (CFA), and formalin in rats up to 44, 67, and 65%, respectively.

Uses

Kirenol is a pharmaceutical agent that induces apoptosis in human chronic myeloid leukemia cells.

Definition

ChEBI: Kirenol is a diterpenoid.

KIRENOL(52659-56-0)Related Product Information

• 12-O-Tiglylphorbol-13 -isobutyrate
• dipotassium dihydrogen 15alpha-hydroxy-2beta-[[2-O-isovaleryl-3,4-di-O-sulphonato-beta-D-glucopyranosyl]oxy]kaur-16-ene-18,19-dioate
• β-Elemonic Acid
• siegesmethyethericacid
• Deacetyltaxol
• 11-Hydroxy-sugiol
• DARUTIGENOL
• FETAL BOVINE SERUM USA ORIGIN GAMMA
• ISOQUERCITRIN
• Bumetanide
• ATRACTYLENOLIDE Ⅲ
• Minoxidil
• Vitexin
• Hydroxysafflor yellow A
• KIRENOL
• 3,3,5,5-TETRAMETHYLCYCLOHEXANOL
• 2,2,4-TRIMETHYL-3-HEXENE
• 1,9-Nonanediol, 2,2,8,8-tetramethyl-