Livmoniplimab
Livmoniplimab Basic information
- Product Name:
- Livmoniplimab
- Synonyms:
-
- Livmoniplimab
- Research Grade Livmoniplimab (DHB91603)
- Research Grade Livmoniplimab
- CAS:
- 2412004-88-5
- MW:
- 0
- Mol File:
- Mol File
More
Less
Livmoniplimab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
More
Less
Livmoniplimab Usage And Synthesis
Uses
Livmoniplimab (ABBV-151) is a monoclonal antibody against GARP/TGF-β1 that can inhibit the release of active TGF-β1. Livmoniplimab has anti-tumor activity in colon cancer mice. Livmoniplimab can be used for the study of locally advanced or metastatic solid tumors[1][2].
in vivo
Livmoniplimab (250 μg; three times a week; 3 weeks; i.p.) exhibits anti-tumor activity in colon cancer mice[2].
| Animal Model: | 7-week-old female B-hGARP mice subcutaneously inoculated with MC38 mouse colon cancer cells[2]. |
| Dosage: | 250 μg |
| Administration: | Intraperitoneal injection (i.p.); three times a week; 3 weeks |
| Result: | Resulted in 34.3% tumor growth inhibition. |
References
[1] Tindall RR, et al. The TGF-β superfamily as potential therapeutic targets in pancreatic cancer. Front Oncol. 2024 Mar 4;14:1362247. DOI:10.3389/fonc.2024.1362247
[2] Guo J, et al. A novel GARP humanized mouse model for efficacy assessment of GARP-targeting therapies. Int Immunopharmacol. 2024 Mar 30;130:111782. DOI:10.1016/j.intimp.2024.111782
LivmoniplimabSupplier
ShangHai Biochempartner Co.,Ltd
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com
Guangzhou Hongyuan Chemical Co.,Ltd
- Tel
- 15817493340
- 981810490@qq.com
Wuhan Chemstan Biotechnology Co., Ltd.
- Tel
- 027-65317797 15926423062
- 422450190@qq.com
Biolab Reagents
- Tel
- 027-65279366 18108604356
- products@biolabreagent.com
Wanxin Biotechnology (Jiaxing) Co., LTD
- Tel
- 0573-83568680 18057391398
- 3956524501@qq.com