2-(Di-tert-butylphosphino)biphenyl CAS#: 224311-51-7

2-(Di-tert-butylphosphino)biphenyl Basic information

Product Name:

2-(Di-tert-butylphosphino)biphenyl

Synonyms:

(2-biphenyl)di-tert-butylphosphine
(2-BIPHENYLYL)DI-TERT-BUTYLPHOSPHINE
2-(DI-TERT-BUTYLPHOSPHINO)BIPHENYL
2-(DI-T-BUTYLPHOSPHINO)BIPHENYL
BIPHENYL-2-YL-DI-TERT-BUTYL-PHOSPHANE
2-(Di-t-butylphosphino)biphenyl,99%JohnPhos
2-(Di-t-butylphosphine) biphenyl
PHOSPHINE, [1,1''-BIPHENYL]-2-YLBIS(1,1-DIMETHYLETHYL)-

CAS:

224311-51-7

MF:

C20H27P

MW:

298.4

EINECS:

607-074-9

Product Categories:

Achiral Phosphine
Aryl Phosphine
Ligand
organophosphine ligand
Buchwald Ligands Series
Buchwald Ligands&Precatalysts
Benzene derivatives
Phosphines
Phosphine Ligands
Synthetic Organic Chemistry

Mol File:

224311-51-7.mol

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2-(Di-tert-butylphosphino)biphenyl Chemical Properties

Melting point:: 86-88 °C (lit.)
Boiling point:: 405.5±24.0 °C(Predicted)
Density: 1 g/cm³
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly, Heated, Sonicated)
form: Crystals or Crystalline Powder
color: White
Water Solubility: Insoluble
BRN: 8322131
Stability:: Air Sensitive
InChI: InChI=1S/C20H27P/c1-19(2,3)21(20(4,5)6)18-15-11-10-14-17(18)16-12-8-7-9-13-16/h7-15H,1-6H3
InChIKey: CNXMDTWQWLGCPE-UHFFFAOYSA-N
SMILES: P(C1=CC=CC=C1C1=CC=CC=C1)(C(C)(C)C)C(C)(C)C
CAS DataBase Reference: 224311-51-7(CAS DataBase Reference)

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Safety Information

Hazard Codes: Xn
Risk Statements: 36/37/38-22
Safety Statements: 36/37/39-26-22
WGK Germany: 3
F: 10-23
TSCA: No
HazardClass: AIR SENSITIVE
HS Code: 29029090

MSDS

Language:English Provider:ACROS
Language:English Provider:SigmaAldrich
Language:English Provider:ALFA

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2-(Di-tert-butylphosphino)biphenyl Usage And Synthesis

Reactions

Ligand used in the palladium-catalyzed synthesis of aromatic amines from aryl chlorides, bromides and triflates.
Ligand employed in a very active and general catalyst for Suzuki coupling reactions using aryl chlorides, bromides and triflates.
Ligand used in palladium-catalyzed synthesis of oxindoles from α-chloroacetanilides.
Effective ligand used in palladium-catalyzed arylation of thiazoles.
Used in the formation of 2-benzylindolines via sequential palladium-catalyzed N-arylation/cyclization/C-arylation.
Selective in the palladium-catalyzed arylation of silyl enol ethers formed from copper-catalyzed reduction of enones.

Chemical Properties

white to light yellow crystal powde

Uses

suzuki reaction

Uses

2-(Di-tert-butylphosphino)biphenyl (also known as JohnPhos) is a Buchwald ligand that is highly efficient in palladium-catalyzed reactions.

General Description

JohnPhos is a Buchwald′s sterically bulky biaryl phosphine ligand. It is a reactive dialkylbiaryl phosphine ligand which catalyzes the carbon-nitrogen bond-forming reactions. Coordination chemistry of gold catalysts bearing JohnPhos as ligand has been investigated by NMR spectroscopy.

2-(Di-tert-butylphosphino)biphenylSupplier

Xinxiang Runyu Material Co., Ltd. Gold

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