Hydroxyacetic Acid Hydrazide Chemical Properties

Melting point:

90-930C

Boiling point:

395.0±25.0 °C(Predicted)

Density 

1.311±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

Acetone, Chloroform, Dichloromethane, Ethyl Acetate, Methanol

form 

Solid

pka

12.46±0.18(Predicted)

color 

White to Off-White

InChI

InChI=1S/C2H6N2O2/c3-4-2(6)1-5/h5H,1,3H2,(H,4,6)

InChIKey

LIUCWHQVLKSECA-UHFFFAOYSA-N

SMILES

C(NN)(=O)CO

CAS DataBase Reference

3530-14-1

Hydroxyacetic Acid Hydrazide Usage And Synthesis

Chemical Properties

White Crystalline Solid

Uses

Hydroxyacetic Acid Hydrazide (cas# 3530-14-1) is a compound useful in organic synthesis.

Synthesis

A. Synthesis of 2-hydroxyacetylhydrazine. Ethyl 2-hydroxyacetate (1.00 g, 9.60 mmol), hydrazine (0.324 mg, 10.1 mmol) and ethanol (20 mL) were mixed in a reaction vial, heated to 85 °C and kept for 3 hours. After completion of the reaction, the reaction mixture was concentrated to afford the target compound 2-hydroxyacetylhydrazine (0.702 g, 81% yield). The product was analyzed by mass spectrometry (ESI) and showed m/z 91.1 [M + 1]+.

References

[1] Molecules, 2016, vol. 21, # 11,
[2] Patent: WO2008/51493, 2008, A2. Location in patent: Page/Page column 196
[3] Chemical Biology and Drug Design, 2016, vol. 88, # 6, p. 873 - 883
[4] Patent: WO2011/77098, 2011, A1. Location in patent: Page/Page column 150
[5] Combinatorial Chemistry and High Throughput Screening, 2011, vol. 14, # 2, p. 132 - 137

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