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CUCURBITACIN D

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CUCURBITACIN D Basic information

Product Name:
CUCURBITACIN D
Synonyms:
  • CUCURBITACIN D
  • ELATERICIN A
  • 20,25-tetrahydroxy-ph
  • cucurbitacine(d)
  • elatericinea
  • CUCURBITACIN D WITH HPLC
  • (10α,23E)-2β,16α,20,25-Tetrahydroxy-9β-methyl-19-norlanosta-5,23-diene-3,11,22-trione
  • Cucurbit D
CAS:
3877-86-9
MF:
C30H44O7
MW:
516.67
Product Categories:
  • Inhibitor
Mol File:
3877-86-9.mol
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CUCURBITACIN D Chemical Properties

Melting point:
151.5°C
Boiling point:
521.47°C (rough estimate)
Density 
1.0814 (rough estimate)
refractive index 
1.5820 (estimate)
storage temp. 
4°C, protect from light
solubility 
Soluble in ethanol and methan
form 
powder
pka
12.66±0.29(Predicted)
color 
White
InChIKey
SRPHMISUTWFFKJ-VZBBWSTBNA-N
SMILES
[C@@]12(C)C[C@@H](O)[C@]([H])([C@](O)(C)C(=O)/C=C/C(O)(C)C)[C@@]1(C)CC(=O)[C@@]1(C)[C@]3([H])C[C@@H](C(=O)C(C)(C)C3=CCC21)O |&1:0,3,5,7,18,23,25,28,r|
LogP
1.480 (est)
CAS DataBase Reference
3877-86-9
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Safety Information

Hazard Codes 
Xi
HS Code 
29144000
Toxicity
LD50 oral in rat: 8200ug/kg
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CUCURBITACIN D Usage And Synthesis

Uses

Cucurbitacin D acts as a potential potent anti-cancer agent in various cervical cancers through induction of apopotosis.

Definition

ChEBI: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23.

in vivo

Cucurbitacin D (1 mg/kg, intratumoral injection, three times a week for four weeks) inhibits tumor proliferation in mice[3].

Animal Model:Xenograft cervical cancer cell model in nude mice[3]
Dosage:1 mg/kg; three times a week; four weeks
Administration:Intratumoral injection
Result:Reduced tumor volume and weight, and the expression of pAKT and pSTAT3 proteins was significantly reduced.

IC 50

HSP90

CUCURBITACIN DSupplier

Guangdong wengjiang Chemical Reagent Co., Ltd. Gold
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+86-028-82633397 18982077548
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Shanghai Winherb Medical Technology Co., Ltd.
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021-38218169 13341702378
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winherb@126.com
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