CUCURBITACIN B
CUCURBITACIN B Basic information
- Product Name:
- CUCURBITACIN B
- Synonyms:
-
- (2beta,9beta,10alpha,16alpha,23e)-thyl
- 19-nor-9-beta,10-alpha-lanosta-5,23-diene-3,11,22-trione,2-beta,16-alpha,20,25
- 19-nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione,2beta,16alpha,20,25-tet
- 19-norlanosta-5,23-diene-3,11,22-trione,25-(acetyloxy)-2,16,20-trihydroxy-9-me
- 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-tr
- Cucurbitacin B hydrate
- Cucurbitacin B, 98%, from Cucumis melo L.
- cucurbitacineb
- CAS:
- 6199-67-3
- MF:
- C32H46O8
- MW:
- 558.7
- Product Categories:
-
- Tri-Terpenoids
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 6199-67-3.mol
CUCURBITACIN B Chemical Properties
- Melting point:
- 184-186°
- alpha
- D25 +88° (c = 1.55 in ethanol)
- Boiling point:
- 546.74°C (rough estimate)
- Density
- 1.0953 (rough estimate)
- refractive index
- 1.4900 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO: soluble10mg/mL, clear
- form
- powder
- pka
- 12.60±0.29(Predicted)
- color
- white to beige
- λmax
- 290nm(EtOH)(lit.)
- Merck
- 14,2614
- Stability:
- Hygroscopic
- InChIKey
- IXQKXEUSCPEQRD-ALLWXVAWSA-N
Safety Information
- Hazard Codes
- T
- Risk Statements
- 25
- Safety Statements
- 45-24/25
- RIDADR
- UN 2811 6.1 / PGI
- WGK Germany
- 3
- RTECS
- RC6190000
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29153900
- Hazardous Substances Data
- 6199-67-3(Hazardous Substances Data)
- Toxicity
- LD10 orally in mice: 5 mg/kg (LeMen)
CUCURBITACIN B Usage And Synthesis
Description
Cucurbitacin B is a tetracyclic triterpenoid that has been shown to have a strong antitumor activity.
Chemical Properties
White solid
Uses
Cucurbitacin B hydrate has been used:
- as a signal transducer and activator of transcription 3 (stat3) inhibitor to determine its effect on the expression of human lysosomal acid lipase (hLAL) in myeloid-derived suppressor cells (MDSCs).
- as an ecdysone receptor (EcR) antagonist injection to lower the levels of 20-hydoxyecdysone (20E) signaling in butterflies.
- to determine its effect on the cell viability of pancreatic cancer cell lines.
Definition
ChEBI: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated.
Biochem/physiol Actions
Cucurbitacin B is a triterpenoid constituent of Cucurbitaceae plant species. Cucurbitacin B inhibits proliferation in a wide variety of tumor cell lines (IC50 15-30 nM) by inducing apoptosis and inducing cell cycle arrest at G2/M phase. Although the mechanism of action is unclear, Cucurbitacin B inhibits STAT 3 phosphorylation and expression levels and has been shown to block JAK2 activity. Curcubitacin B also inhibits the transcriptional activity of HIF1a and Nf-KB. Curcubitacin B is structurally similar to the JAK inhibitor Curcubitacin I.
CUCURBITACIN BSupplier
- Tel
- 027-02759101766 13125137661
- 2853877621@qq.com
- Tel
- sales@boylechem.com
- Tel
- 010-82848833 400-666-7788
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- Tel
- +86-21-20908456
- sales@BioChemBest.com
- Tel
- 021-67121386
- Sales-CN@TCIchemicals.com
CUCURBITACIN B(6199-67-3)Related Product Information
- CUCURBITACIN D,CUCURBITACIN D WITH HPLC
- CUCURBITACIN E(SH),CUCURBITACIN E,CUCURBITACIN E hplc,CUCURBITACIN E WITH HPLC
- 24-epi-Cucurbitacin G,Cucurbitacin G,Cucurbitacin H
- Cucurbitacin A
- Cucurbitacin F
- Cucurbitacin L
- dihydrocucurbitacin F
- Calebassine
- Cucurbitacin Ia,Cucurbitacin F-25-acetate
- CUCURBITACIN B
- 4-TERT-PENTYLCYCLOHEXANONE
- 4-tert-Butylcyclohexanone
- CUCURBITACIN D(SH)
- Cucurbitacin C
- Cucurbitacin IIb
- CUCURBITACIN IIA
- CUCURBITACIN I WITH HPLC,Cucurbitacin I hydrate,CUCURBITACIN I hplc,CUCURBITACIN I(SH),CUCURBITACIN I
- (E,Z)-2,13-OCTADECADIENOL