ent-idoxuridine
ent-idoxuridine Basic information
- Product Name:
- ent-idoxuridine
- Synonyms:
-
- 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-β-L-erythro-pentofuranosyl)-5-iodo-
- ent-Idoxuridine
- 1-(2-Deoxy-β-L-erythro-pentofuranosyl)-5-iodo-2,4(1H,3H)-pyriMidinedione
- 2'-Deoxy-L-5-iodouridine
- 5-Iodo-2'-deoxy-L-uridine
- Idoxuridine Enantiomer
- Idoxuridine Impurity 1
- CAS:
- 162239-35-2
- MF:
- C9H11IN2O5
- MW:
- 354.1
- Product Categories:
-
- Bases & Related Reagents
- Intermediates & Fine Chemicals
- Nucleotides
- Pharmaceuticals
- Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
- Mol File:
- 162239-35-2.mol
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ent-idoxuridine Chemical Properties
- InChI
- InChI=1/C9H11IN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5?,6-,7-/s3
- InChIKey
- XQFRJNBWHJMXHO-WGPDPFDPNA-N
- SMILES
- N1C(=O)C(I)=CN([C@@H]2CC(O)[C@H](CO)O2)C1=O |&1:7,11,r|
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ent-idoxuridine Usage And Synthesis
Description
Ent-Idoxuridine, also known as 5-iodo-2'-deoxyuridine, is a cytosolic DNA synthesis inhibitor that acts by blocking the conversion of deoxycytidine to deoxyadenosine through the inhibition of the enzyme deoxycytidine kinase. As an enantiomer of idoxuridine, it shares the exact mechanism of action. Notably, ent-idoxuridine is resistant to exonucleases and has demonstrated effectiveness in treating immunodeficiency caused by HIV.
Uses
The enantiomer of Idoxuridine (I205750). Antitumor nucleoside enantiomer thymidine kinase used as potential antiviral agents.
ent-idoxuridineSupplier
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