Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Nucleoside drugs >  Nucleotides and their analogs >  Thymidine

Thymidine

Basic information Safety Supplier Related

Thymidine Basic information

Product Name:
Thymidine
Synonyms:
  • 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-beta-D-ribofuranosyl)-5-methyl-
  • -Nerve Growth Factor (NGF), Induction of neurite outgrowth in PC12 cells, Human recombinant, 27kD
  • SS-THYMIDINE
  • 1-(2-Deoxy-β-D-ribofuranosy
  • ThymidineForBiochemistry
  • ThymidineForBiochemistry-(ThymineDeoxyriboside)
  • b-Thymidine
  • Thymidine,>96%
CAS:
50-89-5
MF:
C10H14N2O5
MW:
242.23
EINECS:
200-070-4
Product Categories:
  • Miscellaneous Specialties
  • Zidovudine
  • Stavudine
  • Biochemistry
  • Nucleosides and their analogs
  • Nucleosides, Nucleotides & Related Reagents
  • Pyridines, Pyrimidines, Purines and Pteredines
  • chiral
  • Anti-virals
  • Bases & Related Reagents
  • Carbohydrates & Derivatives
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
  • FINE Chemical & INTERMEDIATES
  • API intermediates
  • Pyrimidine purine
  • nucleoside
  • Nucleosides
  • Modified(deoxy)nucleoside
Mol File:
50-89-5.mol
More
Less

Thymidine Chemical Properties

Melting point:
186-188 °C(lit.)
alpha 
18.6 º (c=3, H2O)
Boiling point:
385.05°C (rough estimate)
Density 
1.3129 (rough estimate)
refractive index 
33 ° (C=1, 1mol/L NaOH)
storage temp. 
2-8°C
solubility 
Acetone, DMSO (Slightly), Ethanol, Ethyl Acetate, Methanol (Slightly, Heated), P
pka
pK1:9.79;pK2:12.85 (25°C)
form 
Crystalline Powder
color 
White to almost white
optical activity
[α]20/D +19±1°, c = 1% in H2O
Water Solubility 
SOLUBLE
Merck 
14,9397
BRN 
89285
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
IQFYYKKMVGJFEH-XLPZGREQSA-N
LogP
-0.930
CAS DataBase Reference
50-89-5(CAS DataBase Reference)
NIST Chemistry Reference
Thymidine(50-89-5)
EPA Substance Registry System
Thymidine (50-89-5)
More
Less

Safety Information

Hazard Codes 
Xi
Risk Statements 
20/21/22-40-36/37/38-68
Safety Statements 
22-24/25-37/39-26-36/37/39
WGK Germany 
3
RTECS 
XP2071000
10
TSCA 
Yes
HS Code 
29335990

MSDS

More
Less

Thymidine Usage And Synthesis

Description

Thymidine is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix. In cell biology it is used to synchronize the cells in G1/early S phase.

Chemical Properties

White needle crystal, soluble in methanol, ethanol, DMSO and other organic solvents.

Physical properties

Thymidine can exist in vitro conditions as a solid (as white crystals or as white crystalline powder). Under standard temperature and pressure, the stability of this compound is very high. As a part of DNA structure, thymidine occurs in living organisms (also in DNA viruses). Therefore, it is a non-toxic compound. In RNA, there is uridine instead of thymidine. Uridine is formed from the combination of uracil with ribose sugar. The key difference between thymine and thymidine is that thymine is a nucleobase, whereas thymidine is a nucleoside.

Uses

Constituent of deoxyribonucleic acid. The nucleoside (deoxyriboside) of thymine. Occurs in DNA. It is a nucleoside consisting of one thymine molecule linked to ad-doxyribose sugar molecule.

Uses

Thymidine is used in the syntheses of active pharmaceutical ingredient such as zidovudine. It also pairs with deoxyadenosine in double-stranded deoxyribonucleic acid. It is used to synchronize the cells in G1/early S phase in cell biology.

Definition

The NUCLEOSIDE formed when thymine is linked to D-ribose by a β-glycosidic bond.

Definition

ChEBI: Thymidine is a pyrimidine 2'-deoxyribonucleoside having thymine as the nucleobase. It has a role as a metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a thymine. It is an enantiomer of a telbivudine.

General Description

Thymidine is also referred to as pyrimidine deoxynucleoside. Deoxythymidine is a nucleoside present in DNA. In a DNA double stranded structure, thymidine pairs with deoxyadeninosine.

Biochem/physiol Actions

Thymidine is useful in cell synchronization during S-phase. In the salvage pathway of pyrimidines, pyrimidine phosphorylase reversibly converts thymine to thymidine.

Mechanism of action

High concentrations of thymidine interrupt the deoxynucleotide metabolism pathway through competitive inhibition, thus blocking DNA replication. A single treatment with thymidine arrests cells throughout S phase, so a double treatment acts to induce a more uniform block in early S phase.

Safety Profile

Moderately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise -thymidine from ethyl acetate, MeOH/Et2O (m 188o) or H2O (as 2H2O m 189o). It is soluble in water and hot organic solvents. The picrate has m 230o (from EtOH).

Thymidine Preparation Products And Raw materials

Preparation Products

ThymidineSupplier

Wuhu Nuowei Chemical Technology Co., Ltd Gold
Tel
0553-8233716 18055326116
Email
sales@nuowei-chem.com
Wuxi Jingyao Bio-Technology Co., Ltd. Gold
Tel
0510-88770633 13961738808
Email
jingyaobiotech@126.com
Xiangyang Meijun Machinery Technology Testing Co., Ltd. Gold
Tel
13774177198
Email
qjuyd@126.com
Hangzhou Hesheng Taiyi Biotechnology Co. , Ltd. Gold
Tel
15868607770
Email
hstysales@126.com
Hubei Henghua Technology Co., Ltd. Gold
Tel
18064208139
Email
2912268575@qq.com