Basic information Safety Supplier Related

trimethylcolchicinic acid methyl ether

Basic information Safety Supplier Related

trimethylcolchicinic acid methyl ether Basic information

Product Name:
trimethylcolchicinic acid methyl ether
Synonyms:
  • trimethylcolchicinic acid methyl ether
  • (S)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one
  • Deacetylcolchicine
  • Desacetylcolchicine
  • (S)-N-Deacetyl Colchicine
  • (7S)-7-Amino-1,2,3,10-Tetramethoxy-6,7-Dihydro-5H-Benzo[g]Heptalen-9-One
  • (-)-7-Deacetylcolchicine
  • (7S)-7-AMino-6,7-dihydro-1,2,3,10-tetraMethoxy-benzo[a]heptalen-9(5H)-one
CAS:
3476-50-4
MF:
C20H23NO5
MW:
357.4
Product Categories:
  • Amines
  • Chiral Reagents
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Amines, Chiral Reagents, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
3476-50-4.mol
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trimethylcolchicinic acid methyl ether Chemical Properties

Boiling point:
490.03°C (rough estimate)
Density 
1.2532 (rough estimate)
refractive index 
1.5614 (estimate)
storage temp. 
-20°C Freezer, Under Inert Atmosphere
solubility 
DMSO: 25mg/mL; Ethanol: 25mg/mL
form 
A crystalline solid
pka
8.62±0.40(Predicted)
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trimethylcolchicinic acid methyl ether Usage And Synthesis

Chemical Properties

Yellow Solid

Uses

An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Definition

ChEBI: Deacetylcolchicine is a carbotricyclic compound, an alkaloid and a member of acetamides.

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