COLCHICOSIDE
COLCHICOSIDE Basic information
- Product Name:
- COLCHICOSIDE
- Synonyms:
-
- Colchicine Impurity 4（Colchicine EP Impurity D）
- Colchicine EP impurity D (Colchicoside)
- Colchicine impurity D
- (S)-7-Acetylamino-6,7-dihydro-3-(β-D-glucopyranosyloxy)-1,2,10-trimethoxybenzo[a]heptalen-9(5H)-one
- Aids012001
- Aids-012001
- N-[3-(Hexopyranosyloxy)-1,2,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[A]heptalen-7-yl]acetamide
- Nsc32992
- CAS:
- 477-29-2
- MF:
- C27H33NO11
- MW:
- 547.554
- EINECS:
- 207-513-0
- Product Categories:
-
- Miscellaneous Natural Products
- Carbohydrates & Derivatives
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 477-29-2.mol
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COLCHICOSIDE Chemical Properties
- Melting point:
- 194-197°C
- Boiling point:
- 620.17°C (rough estimate)
- Density
- 1.3430 (rough estimate)
- refractive index
- 1.6400 (estimate)
- storage temp.
- Refrigerator
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
- pka
- 12.74±0.70(Predicted)
- color
- Light yellow to yellow
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COLCHICOSIDE Usage And Synthesis
Chemical Properties
Pale Yellow Solid
Uses
A significantly toxic Colchicine analog with no anti-inflammatory properties.
Definition
ChEBI: Colchicoside is a carbotricyclic compound, an alkaloid and a member of acetamides.
Purification Methods
Purify colchicoside by chromatography through alumina and eluting with CHCl3, then recrystallising from Me2CO, m 275-280o (after releasing solvent at 180o). It also crystallises from EtOH; see colchicine. The tetraacetate has m 175-177o, [] D 15 -57o (c 1, CHCl3). [Bellet et al. Ann Pharm Fr 10 241 1952, Chem Abstr 47 3323 1953, Beilstein 14 IV 946 for colchicine.]
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