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TRIMETHYLCOLCHICINIC ACID

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TRIMETHYLCOLCHICINIC ACID Basic information

Product Name:
TRIMETHYLCOLCHICINIC ACID
Synonyms:
  • 7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-benzo(a)heptalen-9(5h)-on
  • deacetylcholchiceine
  • desacetylcholchiceine
  • n-deacetyl-colchicein
  • TRIMETHYLCOLCHICINIC ACID
  • N-Deacetyl 10-Demethyl Colchicine
  • trimethyl-colchicinicaci
  • N-DEACETYLCOLCHICEINE
CAS:
3482-37-9
MF:
C19H21NO5
MW:
343.37
EINECS:
222-464-5
Product Categories:
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • All Inhibitors
  • Inhibitors
  • AlkaloidsForensic and Veterinary Standards
  • Chemical Structure
  • Drugs of Abuse
  • Drugs&Metabolites
  • Neat CompoundsDrugs of Abuse
  • OthersAlphabetic
  • TP - TZ
Mol File:
3482-37-9.mol
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TRIMETHYLCOLCHICINIC ACID Chemical Properties

Melting point:
>230°C (dec.)
Boiling point:
478.65°C (rough estimate)
Density 
1.2726 (rough estimate)
refractive index 
1.5000 (estimate)
storage temp. 
−20°C
solubility 
Chloroform (Slightly, Sonicated), DMSO (Slightly), Ethanol (Slightly), Methanol
form 
Solid
color 
Pale Green to Yellow
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
WGK Germany 
3
RTECS 
GH0960000

MSDS

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TRIMETHYLCOLCHICINIC ACID Usage And Synthesis

Description

A minor alkaloid of the colchicine class, this base was first isolated from the seeds and corms of Colchicum autumnale, Gloriosa virescens and Littoria modesta and subsequently by Russian workers from Merendera robusta Bge. Several specific rotations have been measured, e.g. [α]D - 184°, - 152° and - 180° (all in CHC13). The base is separated from the numerous accompanying alkaloids by chromatography and countercurrent distribution.

Chemical Properties

Yellow-green Solid

References

Potesilova, Hrbek, Santavy, Collect. Czech. Chem. Commun., 32, 141 (1967)
Trudykulov, Yusupov, Sadykov, Khim. Prir. Soedin., 8,247 (1972)
Yusupov, Tr. Tashkent Fan., Uzbek SSR, 20, 24 (1972)

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