2-Methoxybenzyl alcohol Chemical Properties

Melting point:

85-86 °C

Boiling point:

248-250 °C(lit.)

Density 

1.039 g/mL at 25 °C(lit.)

vapor pressure 

0.572Pa at 25℃

refractive index 

n20/D 1.547(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

form 

Liquid

pka

14.43±0.10(Predicted)

color 

Clear colorless to light orange-brown

Odor

anisic

Water Solubility 

Not miscible or difficult to mix in water. Soluble in ethanol.

BRN 

2043673

LogP

1.13

CAS DataBase Reference

612-16-8(CAS DataBase Reference)

NIST Chemistry Reference

2-Methoxybenzyl alcohol(612-16-8)

EPA Substance Registry System

Benzenemethanol, 2-methoxy- (612-16-8)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

36/37/38-22

Safety Statements 

23-24/25-37/39-26-36

WGK Germany 

3

F 

9-23

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29094990

MSDS

• Language:English Provider:2-Methoxybenzyl alcohol
• Language:English Provider:SigmaAldrich
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2-Methoxybenzyl alcohol Usage And Synthesis

Chemical Properties

Colorless to light yellow liquid.

Uses

It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals.

Preparation

Synthesis of 2-Methoxybenzyl Alcohol: Under an inert nitrogen (N₂) atmosphere, after dehydration and deoxygenation, 2-methoxybenzoic acid (76.2 mg, 0.5 mmol) was added to the reaction flask, followed by the addition of liquid borane (290 μL, 2 mmol). The reaction was carried out at room temperature for 12 hours. After completion, the mixture was removed from the glovebox, and trimethoxybenzene (84.23 mg, 0.5 mmol) was added as an internal standard. The mixture was dissolved in CDCl₃, stirred for 10 minutes, and then sampled for nuclear magnetic resonance (NMR) analysis. The yield was calculated to be 99%.

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 5629, 1991 DOI: 10.1016/0040-4039(91)80103-D

Flammability and Explosibility

Not classified

References

[1] GIOVANNI PALMISANO . Unexpectedly ambivalent O2 role in the autocatalytic photooxidation of 2-methoxybenzyl alcohol in water[J]. Journal of Molecular Catalysis A: Chemical, 2015, 403: Pages 37-42. DOI:10.1016/j.molcata.2015.03.021.
[2] P. ROVERO. Solid support-dependent alkylation of tryptophan residues in SPPS using a 2-methoxybenzyl alcohol-based linker[J]. Letters in peptide science : LIPS, 1994, 38 1: 149-155. DOI:10.1007/BF00128533.

2-Methoxybenzyl alcohol(612-16-8)Related Product Information

• Benzhydrol
• 4-Methylbenzyl alcohol
• Triphenylmethanol
• Benzyl alcohol
• 4-Hydroxybenzyl alcohol
• Ethyl acetate
• 2-Methyl-1-phenyl-2-propanol
• 3-Phenoxybenzyl alcohol
• 1-(2-METHOXYPHENYL)ETHANOL
• 2-Methoxybenzoic acid
• 2-ETHOXY-1-NAPHTHOIC ACID
• 4-Chloro-2-methoxybenzoic acid
• 2,3,4-Trimethoxybenzoic acid
• 2,4-Dimethoxybenzoic acid
• 2,4,5-Trimethoxybenzoic acid
• 2,6-Dimethoxybenzoic acid
• 3,5-Dimethoxybenzyl alcohol
• 3-METHOXYBENZYL ALCOHOL