Survodutide
Survodutide Basic information
- Product Name:
- Survodutide
- Synonyms:
-
- Survodutide
- BI 456906
- Survodutide Peptide
- Survodutide(BI 456906) 10MG
- Survodutide acetate
- Suvorouti
- Swertide peptide
- Suvodutide
- CAS:
- 2805997-46-8
- MW:
- 0
- EINECS:
- 997-146-8
- Mol File:
- Mol File
Survodutide Chemical Properties
- solubility
- PBS (pH 7.2): Soluble: =10 mg/ml
- form
- Solid
- color
- White to off-white
Survodutide Usage And Synthesis
Uses
Survodutide is a dual glucagon/glucagon-like peptide 1 (GLP1) receptor agonist. Survodutide has demonstrated blood sugar lowering efficacy in a Phase II trial for the treatment of patients with type 2 diabetes and obesity and was associated with clinically meaningful weight loss[1]. Survodutide is also being studied for the treatment of metabolic dysfunction-associated steatohepatitis (MASH)[2].
in vivo
Survodutide (BI 456906; 3, 10, 20, 30 nmol/kg; SC; daily; 30 days) achieves a greater bodyweight-lowering efficacy in diet-induced obese mice compared with maximally effective doses of Semaglutide (HY-114118; 20, 100 nmol/kg). Survodutide dose-dependently reduces plasma glucagon[1].
Survodutide (1, 3, 10, 30, 100 nmol/kg; SC; single dose) dose-dependently reducesacute food intake in WT but not in GLP-1R KO mice (Three-week-old, male, lean NMRI outbred mice)[1].
Survodutide (1, 3, 10, 30, 100 nmol/kg; SC; single dose) engages the glucagon receptor in vivo upon single dosing, increases liver nicotinamide N-methyltransferase mRNA, and reduces plasma serine and glutamine[1].
Survodutide (SC injection) causes mean residence times of 44 and 140 h and Tmax values of 7 and 51 h obtained in mice and dogs, respectively[1].
Pharmacokinetic Parameters of Survodutide (BI 456906) in mice and dogs[1].
| Mice (20 nmol/kg; SC) | Dogs (10 nmol/kg; SC) | |
| Tmax (h) | 7 | 50.7 |
| Cmax (nM) | 84.9 | 62.0 |
| AUC0-∞ (nM?h) | 4640 | 9540 |
| Animal Model: | Male C57BL6/J mice pre-fed with a 60% HFD (22 weeks)[1] |
| Dosage: | 3, 10, 20, 30 nmol/kg |
| Administration: | SC; daily; 30 days |
| Result: | Dose-dependently reduced bodyweight from baseline by up to 32% at Day 28 at a dose of 30 nmol/kg. |
References
[1] BRIAND F, AUGUSTIN R, WESCHE F, et al. 1635-P: Survodutide Weight Loss Is Associated with Changes in Food Preference and Improvement of Dyslipidemia in the Free Choice Diet–Induced Obese Hamster Model[J]. Diabetes, 2024, 33 2. DOI:10.2337/db24-1635-p.
[2] Efficacy, tolerability and pharmacokinetics of survodutide, a glucagon/glucagon-like peptide-1 receptor dual agonist, in cirrhosis[J]. Journal of Hepatology, 2024, 81 5: Pages 837-846. DOI:10.1016/j.jhep.2024.06.003.
[3] TINA ZIMMERMANN . BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy[J]. Molecular Metabolism, 2022, 66: Article 101633. DOI: 10.1016/j.molmet.2022.101633
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