2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole Basic information
- Product Name:
- 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
- Synonyms:
-
- 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
- NS 638
- 1H-Benzimidazol-2-amine,1-[(4-chlorophenyl)methyl]-5-(trifluoromethyl)-
- 1-[(4-Chlorophenyl)Methyl]-5-(Trifluoromethyl)Benzimidazol-2-Amine
- NS-638;NS 638
- NS638, >98%
- 1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine
- 1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine[NS638
- CAS:
- 150493-34-8
- MF:
- C15H11ClF3N3
- MW:
- 325.72
- Mol File:
- 150493-34-8.mol
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2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole Chemical Properties
- Boiling point:
- 476.3±55.0 °C(Predicted)
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol
- form
- A solid
- pka
- 5.15±0.10(Predicted)
- color
- White to off-white
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2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole Usage And Synthesis
Biological Activity
NS-638 is a non-peptidic small molecule with Ca2+-ion channel blocking properties. The IC50 value for intracellular blocking of the increase in Ca2+ concentration activated by K+ was 3.4 μM.
in vivo
In the mouse middle cerebral artery occlusion model, NS-638 administered ip (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days, results in a 48% reduction in total infarct volume. It does not show protection against ischemic neuronal damage in the gerbil model of bilateral carotid artery occlusion.
target
IC50: 3.4 μM (K + -stimulated intracellular Ca 2+ -elevation)
2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazoleSupplier
Shanghai JiYi Biotechnology Co. Ltd.
- Tel
- 13621943973
- sales@shjiyipharmatech.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shanghai Chaolan Chemical Technology Center
- Tel
- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com
Amadis Chemical Company Limited
- Tel
- 571-89925085
- sales@amadischem.com
Beijing Jin Ming Biotechnology Co., Ltd.
- Tel
- 010-60605840 18892239720
- psaitong@jm-bio.com
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2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole(150493-34-8)Related Product Information
- NS 1619
- Selexipag
- NS 11394
- NS-6180
- 1-METHYL-5-TRIFLUOROMETHYLBENZIMIDAZOLE
- 5-METHYL-1H-BENZIMIDAZOL-2-AMINE
- 5-TRIFLUOROMETHYL-1H-BENZIMIDAZOLE
- 1-BENZYL-1H-BENZOIMIDAZOL-2-YLAMINE
- 1-BENZYL-1H-IMIDAZOL-2-YLAMINE
- 5-TRIFLUOROMETHYL-1H-BENZOIMIDAZOL-2-YLAMINE
- 1-(4-Chlorophenylmethyl)-2-aminobenzimidazole
- 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole