Basic information Safety Supplier Related

2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole

Basic information Safety Supplier Related

2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole Basic information

Product Name:
2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
Synonyms:
  • 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
  • NS 638
  • 1H-Benzimidazol-2-amine,1-[(4-chlorophenyl)methyl]-5-(trifluoromethyl)-
  • 1-[(4-Chlorophenyl)Methyl]-5-(Trifluoromethyl)Benzimidazol-2-Amine
  • NS-638;NS 638
  • NS638, >98%
  • 1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine
  • 1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine[NS638
CAS:
150493-34-8
MF:
C15H11ClF3N3
MW:
325.72
Mol File:
150493-34-8.mol
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2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole Chemical Properties

Boiling point:
476.3±55.0 °C(Predicted)
Density 
1.45±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol
form 
A solid
pka
5.15±0.10(Predicted)
color 
White to off-white
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2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole Usage And Synthesis

Biological Activity

NS-638 is a non-peptidic small molecule with Ca2+-ion channel blocking properties. The IC50 value for intracellular blocking of the increase in Ca2+ concentration activated by K+ was 3.4 μM.

in vivo

In the mouse middle cerebral artery occlusion model, NS-638 administered ip (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days, results in a 48% reduction in total infarct volume. It does not show protection against ischemic neuronal damage in the gerbil model of bilateral carotid artery occlusion.

target

IC50: 3.4 μM (K + -stimulated intracellular Ca 2+ -elevation)

2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazoleSupplier

Shanghai JiYi Biotechnology Co. Ltd.
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13621943973
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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Shanghai Chaolan Chemical Technology Center
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QQ:65489617 15618227136
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Amadis Chemical Company Limited
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571-89925085
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sales@amadischem.com
Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 18892239720
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psaitong@jm-bio.com