NS 1619 Chemical Properties

Density 

1.563±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,2-8°C

solubility 

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47 mg/mL

pka

8.32±0.48(Predicted)

form 

solid

color 

white

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

NS 1619 Usage And Synthesis

Uses

NS 1619 is a large conductance calcium-activated potassium channels (BKCa) activator and has been shown to induce precondition in the heart.

Definition

ChEBI: A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It i an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).

Biochem/physiol Actions

NS 1619 is a selective large conductance Ca2+-activated K+-channel activator. The compound is known for its vasodilating and anti-proliferative properties. It is studied that NS 1619 can protect cardiac muscle against ischemia and reperfusion injury.

storage

+4°C

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