15-hexadecynoic acid Chemical Properties

Melting point:

59.1°C (estimate)

Boiling point:

409.64°C (rough estimate)

Density 

0.9310 (rough estimate)

refractive index 

1.4217 (estimate)

storage temp. 

-20°C

solubility 

DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:5): 0.15 mg/ml

form 

A crystalline solid

color 

White to off-white

15-hexadecynoic acid Usage And Synthesis

Description

Alkynyl palmitic acid can be used to identify and characterize the post-translational S-palmitoylation of proteins with Click Chemistry.

Uses

Palmitic acid (15-yne) has been used as a component of fatty acid probe stock solution for the optimization of Alk-C16 incorporation onto cellular proteins. It is also suitable for metabolic labeling.

Uses

15-hexadecynoic acid is a form of palmitic acid with an ω-terminal alkyne. The terminal alkyne group can be used in linking reactions, known as click chemistry; this chemistry is characterized by high dependability and specificity of the azide-alkyne bioconjugation reactions. The use of palmitic acid alkyne and related lipids in isolating palmitoylated proteins has been described.

Biochem/physiol Actions

Alkynyl palmitic acid (aPA) is a modified palmitic acid with an ω-terminal alkyne. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as ‘click chemistry′. The click chemistry reactions are rapid, convenient, versatile and regiospecific. They are easy to purify. aPA can be used for isolating palmitoylated proteins.

IC 50

Alkyl-Chain

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