ALPHA-CGRP (8-37) (RAT)
ALPHA-CGRP (8-37) (RAT) Basic information
- Product Name:
- ALPHA-CGRP (8-37) (RAT)
- Synonyms:
-
- H-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2
- CALCITONIN GENE RELATED PEPTIDE (8-37) RAT
- ALPHA-CALCITONIN GENE-RELATED PEPTIDE (8-37) (RAT)
- ALPHA-CGRP (8-37) (RAT)
- VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2
- VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2
- ALA-CYS-ASP-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2: ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2DISULFIDE BRIDGE CYS2-CYS7
- α-CGRP (8-37) (mouse, rat)
- CAS:
- 129121-73-9
- MF:
- C138H224N42O41
- MW:
- 3127.51
- Product Categories:
-
- Peptide
- Calcitonin and CGRP receptor
- Mol File:
- 129121-73-9.mol
ALPHA-CGRP (8-37) (RAT) Chemical Properties
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- -20°C, protect from light
- solubility
- H2O : 50 mg/mL (15.99 mM; Need ultrasonic)
- form
- Solid
- color
- White to off-white
- Water Solubility
- Soluble to 1 mg/ml in water
- Sequence
- H-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-OH
ALPHA-CGRP (8-37) (RAT) Usage And Synthesis
Uses
Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist.
in vivo
CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a dose-dependent manner. The 50 nM dose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses[1]. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basal levels[2].
storage
Store at -20°C
References
[1] Bennett AD, et al. Alleviation of mechanical and thermal allodynia by CGRP(8-37) in a rodent model of chroniccentral pain. Pain. 2000 May;86(1-2):163-75. DOI:10.1016/s0304-3959(00)00242-6
[2] Yu LC, et al. The calcitonin gene-related peptide antagonist CGRP8-37 increases the latency to withdrawalresponses in rats. Brain Res. 1994 Aug 8;653(1-2):223-30. DOI:10.1016/0006-8993(94)90393-x
ALPHA-CGRP (8-37) (RAT)Supplier
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
- Tel
- 21-61263452 13641803416
- ymbetter@glbiochem.com
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 0551-65326643 18156095617
- info@cellmano.com
ALPHA-CGRP (8-37) (RAT)(129121-73-9)Related Product Information
- H-LEU-LEU-HIS-ASP-LYS-GLY-LYS-SER-ILE-GLN-ASP-LEU-ARG-ARG-ARG-PHE-PHE-LEU-HIS-HIS-LEU-ILE-ALA-GLU-ILE-HIS-THR-ALA-NH2
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