(S)-4-Chloro-3-hydroxybutyronitrile Chemical Properties

Boiling point:

110 °C/1 mmHg(lit.)

Density 

1.250 g/mL at 20 °C(lit.)

refractive index 

n20/D 1.474(lit.)

Flash point:

110 °C

storage temp. 

2-8°C

solubility 

Chloroform (Sparingly), Methanol (Slightly)

pka

12.67±0.20(Predicted)

form 

Oil

color 

Clear Colourless

InChI

InChI=1S/C4H6ClNO/c5-3-4(7)1-2-6/h4,7H,1,3H2/t4-/m0/s1

InChIKey

LHBPNZDUNCZWFL-BYPYZUCNSA-N

SMILES

C(#N)C[C@H](O)CCl

CAS DataBase Reference

127913-44-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

HS Code 

29269090

MSDS

• Language:English Provider:(S)-4-Chloro-3-hydroxybutyronitrile

(S)-4-Chloro-3-hydroxybutyronitrile Usage And Synthesis

Chemical Properties

Colorless to light yellow liqui

Uses

(3S)-4-Chloro-3-hydroxybutyronitrile is used in various organic precursor syntheses. It is used in the synthesis of hydroxypyrrolidinones to by used as carbapenem precursors. Also used in the preparation of atorvastatin (A791750) precursors. Impurity in the synthesis of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.

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