alamifovir
alamifovir Basic information
- Product Name:
- alamifovir
- Synonyms:
-
- LY 582563
- P-[[2-[2-Amino-6-[(4-methoxyphenyl)thio]-9H-purin-9-yl]ethoxy]methyl]phosphonic acid bis(2,2,2-trifluoroethyl) ester
- alamifovir
- MCC 478
- Alamifovir (MCC-478)
- Phosphonic acid, P-[[2-[2-amino-6-[(4-methoxyphenyl)thio]-9H-purin-9-yl]ethoxy]methyl]-, bis(2,2,2-trifluoroethyl) ester
- CAS:
- 193681-12-8
- MF:
- C19H20F6N5O5PS
- MW:
- 575.42
- Mol File:
- 193681-12-8.mol
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alamifovir Chemical Properties
- Melting point:
- 84-85℃
- Boiling point:
- 671.5±65.0 °C(Predicted)
- Density
- 1.60
- form
- Solid
- pka
- 2?+-.0.10(Predicted)
- color
- White to off-white
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alamifovir Usage And Synthesis
Uses
Alamifovir (LY582563; MCC-478), a purine nucleotide analogue proagent, shows potent activity against wild type and lamivudine resistant hepatitis B virus (HBV). Alamifovir has high activity against HBV replication and sustained antiviral effect[1][2].
References
[1] Suzane Kioko Ono-Nita, et al. Novel nucleoside analogue MCC-478 (LY582563) is effective against wild-type or lamivudine-resistant hepatitis B virus. Antimicrob Agents Chemother. 2002 Aug;46(8):2602-5. DOI:10.1128/AAC.46.8.2602-2605.2002
[2] Danny K W Soon, et al. Safety and efficacy of alamifovir in patients with chronic hepatitis B virus infection. J Hepatol. 2004 Nov;41(5):852-8. DOI:10.1016/j.jhep.2004.07.028
alamifovirSupplier
Guangzhou Jhd Chemical Reagent Co., Ltd.
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- 020-84383047
- sales@jhd.com.cn
TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
- marketing@targetmol.com
CONIER CHEM AND PHARMA LIMITED
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- +8618523575427
- sales@conier.com
Chengdu Peter-like Biotechnology Co., Ltd.
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- 028-81700200 13308200041
- 2851167782@qq.com
Biosynth Biological Technology (Suzhou) Co Ltd
- Tel
- 51288865780
- sales@biosynth.com