ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE Chemical Properties

Melting point:

80 °C

Boiling point:

279℃

Density 

1.219

Flash point:

123℃

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

Water Solubility 

Soluble in water

form 

powder to crystal

pka

0.24±0.10(Predicted)

color 

Light yellow to Yellow to Orange

BRN 

1366073

InChI

InChI=1S/C8H11NO2S/c1-3-11-8(10)6-5(2)4-12-7(6)9/h4H,3,9H2,1-2H3

InChIKey

ILYCZKOBLRJJSW-UHFFFAOYSA-N

SMILES

C1(N)SC=C(C)C=1C(OCC)=O

CAS DataBase Reference

43088-42-2(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

HazardClass 

IRRITANT

HS Code 

29349990

MSDS

• Language:English Provider:ALFA

ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE Usage And Synthesis

Application

2-Amino-4-methyl-thiophene-3-carboxylic acid ethyl ester is an ester organic compound that can be used as a pharmaceutical intermediate.

Chemical Properties

Yellow solid

Synthesis

GENERAL METHOD: Cyclohexanone (1.06 mL, 10 mmol), ethyl cyanoacetate (1.15 mL, 10 mmol), morpholine (0.90 mL, 10 mmol), and sulfur powder (0.32 g, 10 mmol) were dissolved in ethanol (10 mL), and the reaction was stirred and refluxed overnight. After completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by distillation under reduced pressure. The resulting crude product was washed with cold ethanol, filtered through a sintered funnel and dried under vacuum. The dried crude product was dissolved in dichloromethane and washed with saturated saline. The organic layer was separated and concentrated under reduced pressure to afford the target compound ethyl 2-amino-4-methylthiophene-3-carboxylate (2a) in 73% yield (1.83 g).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 13, p. 4418 - 4427
[2] European Journal of Medicinal Chemistry, 2014, vol. 86, p. 270 - 278
[3] Patent: CN107151251, 2017, A. Location in patent: Paragraph 0006; 0010
[4] Organic and Biomolecular Chemistry, 2014, vol. 12, # 24, p. 4233 - 4242
[5] Journal of Molecular Catalysis B: Enzymatic, 2013, vol. 95, p. 29 - 35

ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE(43088-42-2)Related Product Information

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• AKOS 89941
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