Methyl 2-broMo-4-chlorobenzoate Chemical Properties

Boiling point:

268.8±20.0 °C(Predicted)

Density 

1.604±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Light yellow

InChI

InChI=1S/C8H6BrClO2/c1-12-8(11)6-3-2-5(10)4-7(6)9/h2-4H,1H3

InChIKey

BIFARHLBYAKSSN-UHFFFAOYSA-N

SMILES

C(OC)(=O)C1=CC=C(Cl)C=C1Br

Safety Information

HS Code 

2916310090

Methyl 2-broMo-4-chlorobenzoate Usage And Synthesis

Chemical Properties

Pale yellow liquid

Uses

Methyl 2-broMo-4-chlorobenzoate is a carboxylic acid ester organic compound used in organic synthesis reactions.   

Synthesis

Step 1: Synthesis of methyl 2-bromo-4-chlorobenzoate. Thionyl chloride (29.2 mL, 400 mmol) was slowly added dropwise to a 500 mL two-necked round-bottomed flask containing 300 mL of anhydrous methanol at 0-5 °C (ice-water bath) for a controlled time of 10 min. After removing the ice water bath, 2-bromo-4-chlorobenzoic acid (25 g, 106 mmol) was added. The reaction mixture was heated to gentle reflux and maintained for 12 hours. The reaction progress was monitored by thin layer chromatography (TLC) and liquid chromatography-mass spectrometry (LCMS). After completion of the reaction, the reaction mixture was concentrated. The crude product was dissolved in 250 mL of dichloromethane (DCM) and washed sequentially with 50 mL of water, 50 mL of saturated aqueous sodium bicarbonate solution and 50 mL of brine. The organic phase was dried over anhydrous sodium sulfate and concentrated to afford methyl 2-bromo-4-chlorobenzoate (26 g, 99% yield), and the product was used directly in subsequent steps without further purification.

References

[1] Patent: US2008/153852, 2008, A1. Location in patent: Page/Page column 19
[2] Patent: CN104045626, 2017, B. Location in patent: Paragraph 0227
[3] Patent: WO2010/55005, 2010, A1. Location in patent: Page/Page column 71
[4] Journal of the American Chemical Society, 2016, vol. 138, # 18, p. 5813 - 5816

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