Methyl 2-bromo-2-methylpropionate Chemical Properties

Boiling point:

52 °C(Press: 19 Torr)

Density 

1.399 g/mL at 20 °C(lit.)

refractive index 

n20/D 1.451

Flash point:

49 °C

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Oil

color 

Colourless

BRN 

1209484

InChIKey

PQUSVJVVRXWKDG-UHFFFAOYSA-N

CAS DataBase Reference

23426-63-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

10-36/37/38

Safety Statements 

26-36

RIDADR 

UN 2929 6.1/PG 2

WGK Germany 

3

F 

19

HS Code 

29159000

MSDS

• Language:English Provider:SigmaAldrich

Methyl 2-bromo-2-methylpropionate Usage And Synthesis

Synthesis

Bromoisobutyric acid (4.17 g, 25 mmol) was dissolved in a solution of concentrated sulfuric acid (0.75 mL) and methanol (50 mL) and stirred under reflux for 2 h. The solution was then cooled to room temperature and concentrated under vacuum. The residue was dissolved in diethyl ether and washed with 10% aqueous sodium bicarbonate, washed with brine, dried under magnesium sulfate, and concentrated again under vacuum. A colorless oil was obtained (4.2 g, 23 mmol, 93% yield) 1H NMR (300 MHz, CDCl3) δ(ppm): 3.78 (s, 3H), 1.93 (s, 6H) 

Uses

Atom Transfer Radical Polymerization (ATRP) initiator that will generate a polymer with a methyl end group

Application

Methyl 2-bromo-2-methylpropionate can be used as a free radical initiator to participate in polymerization reactions.

Synthesis Reference(s)

The Journal of Organic Chemistry, 43, p. 3684, 1978 DOI: 10.1021/jo00413a009

Methyl 2-bromo-2-methylpropionate(23426-63-3)Related Product Information

• Methyl bromoacetate
• Isobutyric acid
• Methyl 4-chlorobutyrate
• METSULFURON METHYL
• 2-Bromobutyric acid methyl ester
• Bromocyclopentane
• Thiophanate-methyl
• Methyl 2-hydroxyisobutyrate
• Kresoxim-methyl
• 2-Bromo-2-methylpropionic acid
• Methyl butyrate
• 1-Bromobutane
• Methyl acrylate
• Phenoxyethyl isobutyrate
• Methylparaben
• 1-Bromododecane
• Methyl isobutyrate
• Methyl (R)-(-)-3-hydroxybutyrate