1-Methyl-2-nonylquinolin-4(1H)-one Chemical Properties

Melting point:

73-75℃

Boiling point:

391.9±42.0 °C(Predicted)

Density 

0.990±0.06 g/cm3(Predicted)

pka

2.53±0.70(Predicted)

1-Methyl-2-nonylquinolin-4(1H)-one Usage And Synthesis

Uses

1-Methyl-2-nonyl-4(1H)-quinolone, a quinolone alkaloid, is a potent and selective MAO-B (monoamine oxidase) inhibitor. 1-Methyl-2-nonyl-4(1H)-quinolone exhibites inhibitory activity on leukotriene biosynthesis, with an IC50 of 12.1 μM[1][2].

Definition

ChEBI: 1-Methyl-2-nonyl-4(1H)-quinolinone is a member of quinolines.

IC 50

MAO-B; MAO-A

References

[1] Han XH, et al. Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase. Arch Pharm Res. 2007 Apr;30(4):397-401. DOI:10.1007/BF02980210
[2] Adams M, et al. Inhibition of leukotriene biosynthesis by quinolone alkaloids from the fruits of Evodia rutaecarpa. Planta Med. 2004 Oct;70(10):904-8. DOI:10.1055/s-2004-832614

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