Gancaonin I Chemical Properties

Boiling point:

534.2±45.0 °C(Predicted)

Density 

1.212±0.06 g/cm3(Predicted)

pka

8.75±0.35(Predicted)

form 

Solid

color 

White to off-white

Gancaonin I Usage And Synthesis

Uses

Gancaonin I, an Isoflavone, exhibits moderate inhibition on human carboxylesterase 2 (hCES2A) with IC50 of 1.72 μM. Gancaonin I inhibits hCES2A-mediated fluorescein diacetate (FD) hydrolysis[1].

Definition

ChEBI: Gancaonin I is a member of the class of 1-benzofurans which consists of 1-benzofuran substituted by methoxy groups at positions 4 and 6, a prenyl group at position 5 and a 2,4-dihydroxyphenyl group at position 2. It has been isolated from Glycyrrhiza uralensis. It has a role as an antibacterial agent and a plant metabolite. It is a member of 1-benzofurans, an aromatic ether and a member of resorcinols. It derives from a hydride of a 1-benzofuran.

References

[1] Yun-Qing Song, et al. Discovery of hCES2A inhibitors from Glycyrrhiza inflate via combination of docking-based virtual screening and fluorescence-based inhibition assays. Food Funct. 2021 Jan 7;12(1):162-176. DOI:10.1039/d0fo02140g

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