Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite CAS#: 1391728-01-0

Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Basic information

Product Name:

Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite

Synonyms:

O-2-cyanoethyl-O'-(3,6-dioxanon-8-ynyl)-N,N-diisopropylphosphoramidite
Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 2-[2-(2-propyn-1-yloxy)ethoxy]ethyl ester
2-cyanoethyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl) diisopropylphosphoramidite

CAS:

1391728-01-0

MF:

C16H29N2O4P

MW:

344.39

Mol File:

1391728-01-0.mol

More

Less

Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Chemical Properties

Boiling point:: 387.2±37.0 °C(Predicted)
pka: 3.53±0.70(Predicted)

More

Less

Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Usage And Synthesis

Biological Activity

Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramiditeSupplier

Borenpharm Co., Ltd

Tel: 027-65563561
Email: sales@borenpharm.com

Jinan elephant international trading co., LTD

Tel
Email: 13006575422@163.com

Alfa Chemistry

Tel
Email: Info@alfa-chemistry.com

Wuhan Borenpharm Co., Ltd

Tel: 027-65563561 18717150066
Email: 3207347307@qq.com

Shaanxi Xinyan Bomei Biotechnology Co., Ltd.

Tel: 029-86217788 13892832556
Email: 2440688701@qq.com

More

Less