Propargyl-PEG1-SS-PEG1-t-butyl ester Chemical Properties

Boiling point:

407.4±40.0 °C(Predicted)

Density 

1.114±0.06 g/cm3(Predicted)

form 

Liquid

color 

Colorless to light yellow

Propargyl-PEG1-SS-PEG1-t-butyl ester Usage And Synthesis

Description

Propargyl-PEG1-SS-PEG1-t-butyl ester is a Click Chemistry crosslinker containing a propargyl group that can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. The t-butyl protected carboxyl group prevents self coupling or polymerization under standard acid/amine or acid/hydroxyl coupling condition, t-butyl can be deprotected under acidic conditions.

Uses

Propargyl-PEG1-SS-PEG1-C2-Boc is a Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG1-SS-PEG1-C2-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG1-SS-PEG1-C2-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

Cleavable Linker; Disulfide Cleavable Linker; Alkyl/ether

References

[1] Barrientos AG, et al. Gold glyconanoparticles: synthetic polyvalent ligands mimicking glycocalyx-like surfaces as tools for glycobiological studies. Chemistry. 2003 May 9;9(9):1909-21. DOI:10.1002/chem.200204544

Propargyl-PEG1-SS-PEG1-t-butyl ester(1807518-78-0)Related Product Information

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