Acid-PEG3-NHS ester Chemical Properties

Boiling point:

516.1±60.0 °C(Predicted)

Density 

1.34±0.1 g/cm3(Predicted)

solubility 

Soluble in DMSO, DCM, DMF

pka

4.28±0.10(Predicted)

Acid-PEG3-NHS ester Usage And Synthesis

Description

Acid-PEG3-NHS ester is a PEG linker containing a carboxylic acid and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Uses

Acid-C2-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Acid-PEG3-NHS ester(1835759-79-9)Related Product Information

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