ACETONE DI-N-BUTYL ACETAL Chemical Properties

Boiling point:

130 °C

Density 

0.84

refractive index 

1.4110-1.4140

form 

clear liquid

color 

Colorless to Almost colorless

CAS DataBase Reference

141-72-0

EPA Substance Registry System

Butane, 1,1'-[(1-methylethylidene)bis(oxy)]bis- (141-72-0)

Safety Information

RIDADR 

3271

TSCA 

TSCA listed

HS Code 

2911.00.5000

HazardClass 

3

PackingGroup 

III

ACETONE DI-N-BUTYL ACETAL Usage And Synthesis

Application

Acetone dibutanol can be used as an organic synthesis intermediate and a pharmaceutical synthesis intermediate, mainly used in laboratory research and development and chemical and pharmaceutical synthesis processes.

Synthesis

N-butanol, i.e., 575 liters or about 465.7 kg (6294 moles) was added to a reactor equipped with a stirring system, a reflux tower and a temperature control system including a water cooling coil system. Then 115 liters, i.e., about 91 kg (1573 moles) of acetone from the acetone collected in Example 1, and 3 kg of Amberlyst 15 sulfonic acid resin, i.e., about 14 molar equivalents of the acid functional group, were introduced. The medium was kept stirred for 1 hour while the temperature was controlled to remain at ambient temperature, and then the medium was allowed to reflux for 6 hours. After returning to ambient temperature, the reactor was allowed to empty by gravity through the filter so as to leave the solid catalyst in the reactor. The resulting mixture was then sent to a distillation column where the residual acetone, excess n-butanol and condensate were separated to give 271 kg of acetone condensed dibutanol as a liquid.

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