4-Bromo-2,6-difluorobenzaldehyde Chemical Properties

Melting point:

76-81 °C

Boiling point:

231.4±40.0℃ (760 Torr)

Density 

1.758±0.06 g/cm3 (20 ºC 760 Torr)

Flash point:

93.7±27.3℃

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to crystal

color 

White to Light yellow to Light orange

Sensitive 

Air Sensitive

InChI

InChI=1S/C7H3BrF2O/c8-4-1-6(9)5(3-11)7(10)2-4/h1-3H

InChIKey

CZGVAISJIQNQEJ-UHFFFAOYSA-N

SMILES

C(=O)C1=C(F)C=C(Br)C=C1F

CAS DataBase Reference

537013-51-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

25

Safety Statements 

45

RIDADR 

2811

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

Ⅲ

HS Code 

29130000

4-Bromo-2,6-difluorobenzaldehyde Usage And Synthesis

Uses

4-Bromo-2,6-difluorobenzaldehyde can be used as organic synthesis and pharmaceutical intermediates, mainly in laboratory research and development, chemical and pharmaceutical production processes.

Synthesis

n-Butyl lithium (0.64ml, 1.2 mmol) was added drop wise to a solution of diisopropyl amine (0.25 mL, 1.5 mmol) in dry THF at -78°C under nitrogen atmosphere over a period of 5 minutes. The reaction mixture was stirred at -20°C for 30 minutes. To this was added 5-bromo-benzo[b]thiophene (200 mg, 0.938 mmol) in dry THF at -78°C, continued stirring for a further 30 minutes at -78°C, followed by the addition of N-chlorosuccinamide (225 mg, 1.68 mmol) in dry THF at -78°C. The resulting mixture was stirred at room temperature for 2 hours. The reaction was monitored by TLC (100% hexane). The reaction mixture was partitioned between ethyl acetate and saturated ammonium chloride. The organic layer was dried over sodium sulfate and concentrated to afford the crude product. Purification by column chromatography on silica gel (100% hexane) afforded the product. Preparation of Intermediate 4-Bromo-2,6-difluoro-benzaldehyde (I-26a): Using analogous reaction condition and reagents as described in Example 20 for the preparation of 1-20a above, 1-bromo-3,5-difluoro-benzene (2 g, 2.10.36 mmol) in THF was reacted with DMF (1.43 g,19.68 mmol), n-butyl lithium (1.56 ml, 12.4 mmol) and diisopropyl amine (0.57 mL, 15.5 mmol) to afford crude product. Purification by column chromatography on silica gel (2% ethyl acetate in hexane) afforded 1.35 g of the product (61% yield). 1H NMR (CDCl3, 300 MHz): δ 11.5-11.0 (s, 1H), 7.4-7.2 (dd, 2H).

4-Bromo-2,6-difluorobenzaldehyde(537013-51-7)Related Product Information

• 2-Bromofluorobenzene
• 4-Bromo-2,6-difluorobenzoic acid
• RARECHEM AL BI 1306
• 4-BROMO-2,3,6-TRIFLUOROBENZALDEHYDE
• 4-Bromo-2,6-difluorobenzaldehyde
• TERT-BUTYL 4-BROMO-2,6-DIFLUOROBENZOATE
• TERT-BUTYL 4-BROMO-2,3,5,6-TETRAFLUOROBENZOATE
• 2,6-Difluorobenzaldehyde
• 4-BROMO-2,6-DIFLUOROBENZOYL CHLORIDE
• 4-BROMO-2,3,5,6-TETRAFLUOROBENZOIC ACID
• RARECHEM AL BF 1308
• RARECHEM AL BI 1308
• Methyl 4-bromo-2,6-difluorobenzoate
• RARECHEM AL BE 1308
• 4-BROMO-2,3,5,6-TETRAFLUOROBENZOYL CHLORIDE