3-AMINO-4-METHOXYPYRIDINE Chemical Properties

Melting point:

83 °C

Boiling point:

270.4±20.0 °C(Predicted)

Density 

1.139±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

form 

solid

pka

7.48±0.18(Predicted)

color 

Brown

InChI

InChI=1S/C6H8N2O/c1-9-6-2-3-8-4-5(6)7/h2-4H,7H2,1H3

InChIKey

STWMPIWLSQKHSJ-UHFFFAOYSA-N

SMILES

C1=NC=CC(OC)=C1N

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-20/21/22

Safety Statements 

36/37

HS Code 

29339900

3-AMINO-4-METHOXYPYRIDINE Usage And Synthesis

Chemical Properties

Off-white solid

Synthesis

Example 93: Synthesis of 4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidine-1-carboxylic acid (7-methoxy-thiazolo[5,4-b]pyridin-2-yl)-amide; Step 1: To a solution of 4-methoxy-3-nitropyridine (5.0 g, 32.44 mmol) in ethanol (100 mL) was added 10% palladium/carbon catalyst (200 mg). The reaction mixture was placed under hydrogen atmosphere (50 psi) and the reaction was shaken at room temperature for 6 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, 50% ethyl acetate/hexane) to confirm complete conversion of the feedstock. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated under reduced pressure to afford 3-amino-4-methoxypyridine (4.0 g, 32.44 mmol, 100% yield), the product was a dark red oil.

References

[1] Patent: US2007/270433, 2007, A1. Location in patent: Page/Page column 47
[2] Patent: WO2012/67664, 2012, A1. Location in patent: Page/Page column 53
[3] Inorganic Chemistry, 2013, vol. 52, # 7, p. 3653 - 3662
[4] Patent: US2011/9405, 2011, A1. Location in patent: Page/Page column 49-50
[5] Chemistry - A European Journal, 2012, vol. 18, # 51, p. 16358 - 16368

3-AMINO-4-METHOXYPYRIDINE(33631-09-3)Related Product Information

• 2-CHLORO-4-METHOXY-3-NITROPYRIDINE
• 4-METHOXY-3-NITROPYRIDINE HYDROCHLORIDE
• 2-AMINO-4-METHOXY-3-NITROPYRIDINE
• 3-Amino-4-ethoxypyridine
• 3-AMINO-4-METHOXYPYRIDINE
• 4-Ethoxy-3-nitropyridine hydrochloride
• 4-Methoxy-3-nitropyridine
• 4-Ethoxy-3-nitropyridine
• 2-AMINO-6-METHOXYPYRIDINE
• 2-amino-4-methoxypyridine-3-carbonitrile
• 2-AMINO-4-METHOXYPYRIDINE
• 4-Amino-6-methoxypyridine,4-AMINO-2-METHOXYPYRIDINE
• 2-BROMO-3-AMINO-6-METHOXYPYRIDINE
• 5-Amino-2-methoxypyridine ,98%,3-Amino-6-methoxypyridin
• 3-Amino-6-methoxypyridine-2-carboxylic acid
• 3-AMINO-2-METHOXYPYRIDINE,3-AMINO-2-METHOXYPYRIDINE 98+%
• 2-Amino-3-methoxypyridine
• 3-AMINO-6-METHOXY-2-METHYLAMINO-PYRIDINE, DIHYDROCHLORIDE SPECIALITY CHEMICALS