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(R)-DIFLUORPHOS(TM)

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(R)-DIFLUORPHOS(TM) Basic information

Product Name:
(R)-DIFLUORPHOS(TM)
Synonyms:
  • (S)-DIFLUORPHOS(TM)
  • S-(+)-5,5'-BIS(DIPHENYLPHOSPHINO)-2,2,2',2'-TETRAFLUORO-4,4'-BI-1,3-BENZODIOXOLE
  • (R)-DIFLUORPHOS(TM)
  • R-(-)-5,5'-BIS(DIPHENYLPHOSPHINO)-2,2,2',2'-TETRAFLUORO-4,4'-BI-1,3-BENZODIOXOLE
  • (S)-DIFLUORPHOS
  • Phosphine,[(4S)-2,2,2'',2''-tetrafluoro[4,4''-bi-1,3-benzodioxole]-5,5''-diyl]bis[diphenyl-
  • S-(+)-5,5'-Bis(diphenylphosphino)-2,2,2',2'-tetrafluoro-4,4'-bi-1,3-benzodioxole,dichloromethaneadduct,min.97%(S)-DIFLUORPHOS
  • S-(+)-5,5'-Bis(diphenylphosphino)-2,2,2',2'-tetrafluoro-4,4'-bi-1,3-benzodioxole, dichloromethane adduct
CAS:
503538-70-3
MF:
C38H24F4O4P2
MW:
682.54
Mol File:
503538-70-3.mol
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(R)-DIFLUORPHOS(TM) Chemical Properties

Boiling point:
670.9±55.0 °C(Predicted)
form 
Powder
color 
white
Sensitive 
air sensitive
CAS DataBase Reference
503538-70-3
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Safety Information

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
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(R)-DIFLUORPHOS(TM) Usage And Synthesis

Reaction

  1. Ligand used for the enantioselective hydrogenation of olefins, and especially electron-poor ketones.
  2. Ligand used for the enantioselective α-arylation of ketones.
  3. Ligand used for enantioselective alkylative aldol reactions.
  4. Nickel-catalyzed asymmetric α-heteroarylation of ketones with chloroarenes.
  5. Palladium-catalyzed asymmetric intramolecular arylation of α-keto amides.

Uses

(S)-DIFLUORPHOS is an electron-poor diphosphane, and can also be used as a chiral supporting ligand.Also, used in preparation of chiral Amino Acid Esters and deuterated Amino Acid Esters.

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