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(1S,2S)-(+)-Pseudoephedrine hydrochloride

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(1S,2S)-(+)-Pseudoephedrine hydrochloride Basic information

Product Name:
(1S,2S)-(+)-Pseudoephedrine hydrochloride
Synonyms:
  • (+)-PSI-EPHEDRINE HYDROCHLORIDE
  • PSI-EPHEDRINE HYDROCHLORIDE
  • PSEUDOEPHEDRINE HCL
  • PSEUDOEPHEDRINE HCL, (+)-1S,2S-
  • (+)-PSEUDOEPHEDRINE HYDROCHLORIDE
  • PSEUDOEPHEDRINE HYDROCHLORIDE
  • a)]-
  • alpha-(1-(methylamino)ethyl)-,hydrochloride,(s-(r*,r*))-benzenemethano
CAS:
345-78-8
MF:
C10H16ClNO
MW:
201.69
EINECS:
206-462-1
Product Categories:
  • Pharmaceutical Raw Materials
  • Amines
  • Aromatics
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • API's
Mol File:
345-78-8.mol
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(1S,2S)-(+)-Pseudoephedrine hydrochloride Chemical Properties

Melting point:
185-188 °C(lit.)
alpha 
61 º (c=5, H2O,2dm tube)
storage temp. 
Refrigerator (+4°C)
solubility 
Freely soluble in water and in ethanol (96 per cent), sparingly soluble in methylene chloride.
form 
neat
pka
9.22(at 25℃)
Merck 
13,8007
BRN 
3915112
CAS DataBase Reference
345-78-8(CAS DataBase Reference)
EPA Substance Registry System
Benzenemethanol, .alpha.-[(1S)-1-(methylamino)ethyl]-, hydrochloride, (.alpha.S)- (345-78-8)
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Safety Information

Hazard Codes 
Xn,T,F
Risk Statements 
22-36/37/38-36/38-39/23/24/25-23/24/25-11
Safety Statements 
26-36-24/25-45-36/37-16-7
RIDADR 
1544
WGK Germany 
3
RTECS 
UL5950000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29394200
Toxicity
LD50 i.p. in mice: 1.0 mmole/kg (Fairchild, Alles)

MSDS

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(1S,2S)-(+)-Pseudoephedrine hydrochloride Usage And Synthesis

Chemical Properties

white powder

Uses

Non-selective adrenergic agonist; decongestant (nasal). Controlled precursor.

Definition

ChEBI: A hydrochloride that is the monohydrochloride salt of pseudoephedrine.

brand name

Efidac (ALZA); Novafed (Sanofi Aventis); Sudafed (GlaxoSmithKline); Sudafed (Warner Lambert).

Contact allergens

This sympathomimetic a-adrenergic agonist is found in plants of the genus Ephedra (Ephedraceae) and is systemically used as a nasal decongestant. It can induce drug skin reactions such as acute generalized exanthematic pustulosis or generalized eczema.

Purification Methods

1S,2S-Pseudoephedrine hydrochloride [345-78-8] M 210.7, m 181-182o, 185-188o, [ + 6 1o (c 1 H2O). Crystallise the salt from EtOH. [Beilstein 13 IV 1878.]

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