CFM 4 Chemical Properties

Boiling point:

653.4±65.0 °C(Predicted)

Density 

1.39±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in DMSO (greater than 25 mg/ml)

form 

solid

pka

0.13±0.20(Predicted)

color 

Tan

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

CFM 4 Usage And Synthesis

Description

CFM-4 (331458-02-7) is a CARP-1 functional mimetic that interferes with CARP-1 binding to APC-2 (IC50=10-15 μM).1 Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses growth of medulloblastoma cells2 and malignant pleural mesothelioma cells3.

References

1) Puliyappadamba et al. (2011), Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis; J. Biol. Chem. 286 38000 2) Ashour et al. (2013), CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth; PLoS ONE 8 e66733 3) Jamal et al. (2014), CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells; PLoS ONE 9 e89146

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