Choline dihydrogencitrate salt Chemical Properties

Melting point:

105-107.5°

storage temp. 

2-8°C

solubility 

DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White to Off-White

Water Solubility 

almost transparency

Merck 

14,2207

Stability:

Hygroscopic

LogP

-1.721 (est)

CAS DataBase Reference

77-91-8(CAS DataBase Reference)

EPA Substance Registry System

Choline citrate (1:1) (77-91-8)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

2

RTECS 

GA2582000

HS Code 

29231000

MSDS

• Language:English Provider:SigmaAldrich

Choline dihydrogencitrate salt Usage And Synthesis

Chemical Properties

White crystalline powder

Originator

Chothyn, Flint, US,1945

Uses

Choline Dihydrogen Citrate can be used to synthesize compounds that can improve the photosynthetic efficiency of plants. It can also be used for synthesizing cleaning compounds that can be used for dishwashing, oven cleaning, microwave oven cleaning, floor cleaning, or surface cleaning. Furthermore, Choline Dihydrogen Citrate can potentially be used in the treatment of multiple sclerosis. Additionally, Choline Dihydrogen Citrate can also be use as a component of a nutritional supplement that can be used for improving cerebral activity.

Manufacturing Process

30 lb of trimethylamine were added to 70.4 lb of methyl alcohol to which 9.2 lb of water had previously been added. To the resulting solution in a closed vessel 23 lb of ethylene oxide gas were introduced and the resulting mixture then maintained at a temperature of 16 C to 30 C and agitated for 6 hours. During the reaction the pressure in the reaction vessel varied from about 17.5 psi at the start of the reaction to 0 psi at the end of the reaction. The resulting solution was then added with agitation to a refluxing solution of 40 liters of isopropyl alcohol containing 95 lb of citric acid dissolved therein. This mixture was then cooled to 0°C and held at that temperature overnight. The white crystalline choline dihydrogen citrate which formed was separated from the solvent mixture by filtration and dried in vacuo. 117 lb of anhydrous, crystalline choline dihydrogen citrate having a purity of 99.6% were obtained. This was a yield of 78% based on the amount of trimethylamine employed.

Therapeutic Function

Lipotropic

Biochem/physiol Actions

Acyl group acceptor

Choline dihydrogencitrate salt(77-91-8)Related Product Information

• Choline hydroxide
• Tetraethylammonium hydroxide
• Ammonium ferric citrate
• Calcium citrate
• Ammonium citrate dibasic
• Tetraethylammonium bromide
• Disodium citrate
• SODIUM DIHYDROGEN CITRATE
• Mosapride citrate
• Hydroxyethyl starch
• Zinc citrate
• Citicoline sodium
• Sildenafil citrate
• Citric acid
• Sodium citrate
• POTASSIUM DIHYDROGEN CITRATE
• Hydroxyethyl Cellulose
• Citiolone