2-Bromo-4-fluoronitrobenzene Chemical Properties

Melting point:

44 °C

Boiling point:

70-75 °C(Press: 0.4 Torr)

Density 

1.808±0.06 g/cm3(Predicted)

refractive index 

1.57

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

Solid

color 

Pale yellow to green

InChI

InChI=1S/C6H3BrFNO2/c7-5-3-4(8)1-2-6(5)9(10)11/h1-3H

InChIKey

VGYVBEJDXIPSDL-UHFFFAOYSA-N

SMILES

C1([N+]([O-])=O)=CC=C(F)C=C1Br

CAS DataBase Reference

700-36-7

Safety Information

Safety Statements 

24/25

HS Code 

29049090

2-Bromo-4-fluoronitrobenzene Usage And Synthesis

Chemical Properties

Yellow to pale green powder

Uses

2-Bromo-4-fluoro-1-nitrobenzene can be used as a valuable building block, mainly for the preparation of Benzimidazoles.

Synthesis

General procedure for the synthesis of 1-bromo-5-fluoro-2-nitrobenzene from 4-fluoroaniline: N-bromosuccinimide (34 g, 180 mmol) was dissolved in dichloromethane (60 mL) at 0 °C and slowly added dropwise to a solution of 4-fluoroaniline (20 g, 180 mmol) in dichloromethane (100 mL). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, it was washed sequentially with saturated sodium sulfite solution, saturated sodium bicarbonate solution and brine, and then concentrated to give 1-bromo-5-fluoro-2-nitrobenzene (34 g, 154.5 mmol, 100% yield). The 1H NMR (400 MHz, CDCl3) data of the product were as follows: δ 7.12-7.21 (m, 1H), 7.47 (dd, J = 7.60, 2.40 Hz, 1H), (dd, J = 9.60, 6.40 Hz, 1H).

References

[1] Patent: US2008/300242, 2008, A1. Location in patent: Page/Page column 62

2-Bromo-4-fluoronitrobenzene(700-36-7)Related Product Information

• 4-Bromobenzotrifluoride
• 4-Fluoronitrobenzene
• 3,4-Difluoronitrobenzene
• 3-Bromoanisole
• Ethyl bromodifluoroacetate
• 2-Bromo-4,5-difluoronitrobenzene
• 3-Bromonitrobenzene
• Bromine
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• BROMOTRIFLUOROMETHANE
• Acrolein
• 1-Bromo-2-fluoro-4-nitrobenzene
• 4-BROMO-2-FLUORO-6-NITROANISOLE
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• 1-BROMO-4-FLUORO-2-NITROBENZENE
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