CC-90001
CC-90001 Basic information
- Product Name:
- CC-90001
- Synonyms:
-
- CC90001
- CC-90001
- CC90001 free base
- CC90001,kinase,IPF,JNK,c-Jun,idiopathic,JNK1,Inhibitor,N-terminal,inhibit,CC-90001,CC 90001,fibrosis,pulmonary
- 5-Pyrimidinecarboxamide, 2-[(1,1-dimethylethyl)amino]-4-[[(1R,3R,4R)-3-hydroxy-4-methylcyclohexyl]amino]-
- 2-(tert-Butylamino)-4-(((1R,3R,4R)-3-hydroxy-4-methylcyclohexyl)amino)pyrimidine-5-carboxamide
- CC-90001, 10 mM in DMSO
- CAS:1403859-14-2
- CAS:
- 1403859-14-2
- MF:
- C16H27N5O2
- MW:
- 321.42
- Mol File:
- 1403859-14-2.mol
CC-90001 Chemical Properties
- Boiling point:
- 549.5±60.0 °C(Predicted)
- Density
- 1.224±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 250 mg/mL (777.80 mM; Need ultrasonic)
- pka
- 14.17±0.50(Predicted)
- form
- Solid
- color
- White to yellow
CC-90001 Usage And Synthesis
Uses
CC-90001 is a potent, selective and orally active inhibitor of c-Jun N-terminal kinase (JNK). CC-90001 shows 12.9-fold selectivity for JNK1 over JNK2 in a cell-based model. CC-90001 can be used for the research of idiopathic pulmonary fibrosis[1][2].
in vivo
CC-90001 (3 mg/kg b.i.d.) reduces the development of fibrosis, as evidenced by a 48% reduction in collagen and a 53% reduction in α-smooth muscle actin (α-SMA) in a steatohepatitis model[1].
CC-90001 decreases multiple measures of lung collagen and reduces disease induced increases in α-SMA to nearly baseline levels in a house dust mite model of lung fibrosis[1].
IC 50
JNK1; JNK2
References
[1] Bennett B, et, al. CC-90001, a Second Generation Jun N-Terminal Kinase (JNK) Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine 2017; 195:A5409.
[2] Kolb M, et, al. Therapeutic targets in idiopathic pulmonary fibrosis. Respir Med. 2017 Oct;131:49-57. DOI:10.1016/j.rmed.2017.07.062
CC-90001Supplier
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