CC-92480
CC-92480 Basic information
- Product Name:
- CC-92480
- Synonyms:
-
- CC-92480
- Benzonitrile, 4-[4-[[4-[[[2-[(3S)-2,6-dioxo-3-piperidinyl]-2,3-dihydro-1-oxo-1H-isoindol-4-yl]oxy]methyl]phenyl]methyl]-1-piperazinyl]-3-fluoro-
- CC92489
- Mezigdomide
- (S)-4-(4-(4-(((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile
- RSYY（Avanafil)-4
- CC 92480,Molecular Glues,Ubiquitin ligase,Ubiquitin activating enzyme,E1/E2/E3 Enzyme,Apoptosis,inhibit,E1 activating enzyme,Mezigdomide,E2 conjugating enzyme,Inhibitor,Ubiquitin conjugating enzyme,CC92480,E3 ligating enzyme
- Avanafil Impurity 80
- CAS:
- 2259648-80-9
- MF:
- C32H30FN5O4
- MW:
- 567.61
- Mol File:
- 2259648-80-9.mol
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CC-92480 Chemical Properties
- Boiling point:
- 833.0±65.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble
- form
- A solid
- pka
- 10.70±0.40(Predicted)
- color
- White to off-white
- InChIKey
- YTINZZFBHWSAGL-NDEPHWFRSA-N
- SMILES
- C(#N)C1=CC=C(N2CCN(CC3=CC=C(COC4=CC=CC5=C4CN([C@H]4CCC(=O)NC4=O)C5=O)C=C3)CC2)C(F)=C1
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CC-92480 Usage And Synthesis
Uses
Mezigdomide (CC-92480), a cereblon E3 ubiquitin ligase modulating agent (CELMoD), acts as a molecular glue. Mezigdomide shows high affinity to cereblon, resulting in potent antimyeloma activity[1].
References
[1] Nooka AK, et al. Mechanism of Action and Novel IMiD-Based Compounds and Combinations in Multiple Myeloma. Cancer J. 2019 Jan/Feb;25(1):19-31. DOI:10.1097/PPO.0000000000000354
CC-92480Supplier
Sichuan Yiyan Pharmaceutical Research Gold
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- 19949968070; 19949968070
- 2904199885@qq.com
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
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- 17702719238 18971495150;
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ChemCell Biomedicine Co.,Ltd.
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- 020-13556033878 2965585218 13556033878
- chemcell@hotmail.com
Shanghai Topbiochem Technology Co., Ltd
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- 021-58170097
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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- 028-81700200 18116577057
- 3003855609@qq.com